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Titolo:
B cell co-receptors regulating T cell-dependent antibody production in common variable immunodeficiency: CD27 pathway defects identify subsets of severely immuno-compromised patients.
Autore:
Jacquot, S; Macon-Lemaitre, L; Paris, E; Kobata, T; Tanaka, Y; Morimoto, C; Schlossman, SF; Tron, F;
Indirizzi:
CHU Charles Nicolle, Fac Med & Pharm, INSERM U519,IFRMP 23, Lab Immunopathol Clin & Expt, F-76183 Rouen, France CHU Charles Nicolle Rouen France F-76183 n & Expt, F-76183 Rouen, France Univ Ryukyus, Sch Med, Okinawa Asia Res Ctr Med Sci, Dept Infect Dis & Immunol, Okinawa 9030215, Japan Univ Ryukyus Okinawa Japan 9030215 Dis & Immunol, Okinawa 9030215, Japan Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Immunol & AIDS,DivTumor Immunol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 S,DivTumor Immunol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA Harvard Univ BostonMA USA 02115 Sch Med, Dept Med, Boston, MA 02115 USA
Titolo Testata:
INTERNATIONAL IMMUNOLOGY
fascicolo: 7, volume: 13, anno: 2001,
pagine: 871 - 876
SICI:
0953-8178(200107)13:7<871:BCCRTC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA-CELLS; DIFFERENTIATION; CD27/CD70; ANTIGEN; COSTIMULATION; GENERATION; CD154/CD40; ACTIVATION; EXPRESSION; CD70/CD27;
Keywords:
memory B cells; T-B interactions; tumor necrosis factor receptor family;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Jacquot, S CHU Charles Nicolle, Fac Med & Pharm, INSERM U519,IFRMP 23, LabImmunopathol Clin & Expt, 22 Blvd Gambetta, F-76183 Rouen, France CHU Charles Nicolle 22 Blvd Gambetta Rouen France F-76183 ance
Citazione:
S. Jacquot et al., "B cell co-receptors regulating T cell-dependent antibody production in common variable immunodeficiency: CD27 pathway defects identify subsets of severely immuno-compromised patients.", INT IMMUNOL, 13(7), 2001, pp. 871-876

Abstract

CD27 and CD134 ligand (CD134L) are two B cell co-receptors for T-h cell activation-induced ligands (i.e. CD70 and CD134) that promote differentiationof B cells into plasma cells and high-rate antibody production respectively. We explored the CD27 pathway and T cell CD134 expression in common variable immunodeficiency (CVID), a disease characterized by a lack of plasma cells and low Ig serum levels. Twelve patients were compared to seven healthycontrols. We found a low percentage of circulating CD27(+) B cells in seven patients and B cell CD27 expression was not upregulated by in vitro activation in two of them. Importantly, the number of circulating CD27(+) B cells was correlated with the severity of the disease-the patients with the lowest CD27(+) B cell counts having the lowest serum Ig concentrations and thelowest total peripheral blood 13 cell counts. In contrast, CD70 and CD134 were normally expressed on in vitro activated T cells. CD134L was not detected on patient and control IS cells in our activation conditions. Functional studies of in vitro Ig production demonstrated an absence of B cell response to CD27 cross-linking, in particular in a patient with normal CD27 expression. Our results indicate that a defect in CD27 expression or function contributes to the pathogenesis of certain severe forms of CVID.

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Documento generato il 09/07/20 alle ore 15:32:25