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Titolo:
The expression of IL-12 p40 and its homologue Epstien-Barr virus-induced gene 3, in inflammatory bowel disease
Autore:
Omata, F; Birkenbach, M; Matsuzaki, S; Christ, AD; Blumberg, RS;
Indirizzi:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Gastroenterol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Div Gastroenterol, Boston, MA 02115 USA Eastern Virginia Med Sch, Dept Pathol & Anat, Norfolk, VA 23501 USA Eastern Virginia Med Sch Norfolk VA USA 23501 Anat, Norfolk, VA 23501 USA Tokai Univ, Sch Med, Div Gastroenterol, Kanagawa 2591100, Japan Tokai Univ Kanagawa Japan 2591100 Gastroenterol, Kanagawa 2591100, Japan
Titolo Testata:
INFLAMMATORY BOWEL DISEASES
fascicolo: 3, volume: 7, anno: 2001,
pagine: 215 - 220
SICI:
1078-0998(200108)7:3<215:TEOIPA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-KAPPA-B; CROHNS-DISEASE; ULCERATIVE-COLITIS; INTERLEUKIN-12 EXPRESSION; RT-PCR; CYTOKINE; CELLS; ANTIBODIES; PROFILES; MUCOSA;
Keywords:
Epstein-Barr virus-induced gene 3; interleukin-12; ulcerative colitis; Crohn's disease; real-time polymerase chain reaction; 5-aminosalicylate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Blumberg, RS Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Gastroenterol, 75 Francis St, Boston, MA 02115 USA Harvard Univ 75 Francis St Boston MA USA 02115 , MA 02115 USA
Citazione:
F. Omata et al., "The expression of IL-12 p40 and its homologue Epstien-Barr virus-induced gene 3, in inflammatory bowel disease", INFLAMM B D, 7(3), 2001, pp. 215-220

Abstract

Background: It has recently been suggested that Crohn's Disease (CD) is associated with an exaggerated T helper I cytokine response as manifest by increased production of interleukin-12 (IL-12) and interferon-gamma (IFN-gamma). Epstein-Barr virus-induced gene 3 (EBI3) encodes a 34-kDa glycoprotein that is 27% identical to the p40 unit of IL-12 and has recently been reported to be up-regulated in ulcerative colitis (UC). Aim: To determine whethermucosal expression of IL-12 p40 or EBI3 correlates with inflammatory boweldisease (IBD). Patients/Methods: mRNA expression in colonic mucosa from patients with UC, Crohn's disease (CD) and non-IBD controls was measured by reverse-transcribed real-time polymerase chain reaction (PCR). Results: EBI3was significantly increased in both involved and uninvolved colonic mucosain patients with UC. Although IL-12 p40 was increased in some patients with CD relative to non-IBD controls, the increase was not statistically significant. However, 5-aminosalicylic acid (5-ASA) use was significantly correlated with reduced IL-12 p40 levels in the patients with CD, but not in UC cases. A similar reduction was not seen in 5-ASA-treated UC patients. Conclusion: IL-12 p40 expression in CD is heterogeneous. In contrast, expression of the IL-12 p40 homologue, EBI3, is up-regulated in nearly all UC cases and in a subset of CD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 00:26:09