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Titolo:
Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes
Autore:
Martin, F; Malergue, F; Pitari, G; Philippe, JM; Philips, S; Chabret, C; Granjeaud, S; Mattei, MG; Mungall, AJ; Naquet, P; Galland, F;
Indirizzi:
Univ Aquila, Dipartimento Biol Base & Apllicata, I-67010 Coppito, Italy Univ Aquila Coppito Italy I-67010 se & Apllicata, I-67010 Coppito, Italy Sanger Ctr, Cambridge CB10 1SA, England Sanger Ctr Cambridge England CB10 1SA r Ctr, Cambridge CB10 1SA, England Hop Enfants La Timone, Unite Genet Med & Dev, INSERM U406, F-13385 Marseille, France Hop Enfants La Timone Marseille France F-13385 F-13385 Marseille, France
Titolo Testata:
IMMUNOGENETICS
fascicolo: 4, volume: 53, anno: 2001,
pagine: 296 - 306
SICI:
0093-7711(200105/06)53:4<296:VGAC(6>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR ADHESION PROTEIN-1; PANTOTHENIC-ACID; MOLECULE; BIOTINIDASE; MIGRATION; RECEPTOR; EXPRESSION; SUGGESTS; SEQUENCE; TAURINE;
Keywords:
gene cluster; human chromosome 6; ectoenzymes; pantetheinase; oxidative stress; tissue repair;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Galland, F Univ Mediterranee, CNRS, INSERM, Ctr Immunol Marseille Luminy, Parc Sci deLuminy,Case 906, F-13288 Marseille 09, France Univ Mediterranee Parc Sci de Luminy,Case 906 Marseille France 09
Citazione:
F. Martin et al., "Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes", IMMUNOGENET, 53(4), 2001, pp. 296-306

Abstract

The mouse Vanin-1 molecule plays a role in thymic reconstitution followingdamage by irradiation. We recently demonstrated that it is a membrane pantetheinase (EC 3.56.1.-). This molecule is the prototypic member of a largerVanin family encoded by at least two mouse (Vanin-1 and Vanin-3) and threehuman (VNN1, VNN2, VNN3) orthologous genes. We now report (1) the structural characterization of the human and mouse Vanin genes and their organization in clusters on the 6q22-24 and 10A2B1 chromosomes, respectively; (2) identification of the human VNN3 gene and the demonstration that the mouse Vanin-3 molecule is secreted by cells, and (3) that the Vanin genes encode different isoforms of the mammalian pantetheinase activity. Thus, the Vanin family represents a novel class of secreted or membrane-associated ectoenzymes. We discuss here their possible role in processes pertaining to tissue repair in the context of oxidative stress.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:48:06