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Titolo:
MICA engagement by human V gamma 2V delta 2 T cells enhances their antigen-dependent effector function
Autore:
Das, H; Groh, V; Kuijl, C; Sugita, M; Morita, CT; Spies, T; Bukowski, JF;
Indirizzi:
Brigham & Womens Hosp, Lymphocyte Biol Sect, Div Rheumatol Immunol & Allergy, Dept Med, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 Dept Med, Boston, MA 02115 USA Harvard Univ, Sch Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 vard Univ, Sch Med, Boston, MA 02115 USA Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98109 , Seattle, WA 98109 USA Univ Iowa, Dept Internal Med, Div Rheumatol, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 , Div Rheumatol, Iowa City, IA 52242 USA Univ Iowa, Interdisciplinary Grp Immunol, EMRB 340F, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 unol, EMRB 340F, Iowa City, IA 52242 USA
Titolo Testata:
IMMUNITY
fascicolo: 1, volume: 15, anno: 2001,
pagine: 83 - 93
SICI:
1074-7613(200107)15:1<83:MEBHVG>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRENYL PYROPHOSPHATE ANTIGENS; DELTA LYMPHOCYTES-T; GAMMA-DELTA; NONPEPTIDE ANTIGENS; INNATE IMMUNITY; RECEPTOR; RECOGNITION; ACTIVATION; INFECTION; MOLECULES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Bukowski, JF Brigham & Womens Hosp, Lymphocyte Biol Sect, Div Rheumatol Immunol & Allergy, Dept Med, 75 Francis St, Boston, MA 02115 USA Brigham & Womens Hosp 75 Francis St Boston MA USA 02115 5 USA
Citazione:
H. Das et al., "MICA engagement by human V gamma 2V delta 2 T cells enhances their antigen-dependent effector function", IMMUNITY, 15(1), 2001, pp. 83-93

Abstract

V gamma 2V delta2 T cells comprise 2%-5% of human peripheral blood T cells, recognize ubiquitous nonpeptide antigens, and expand up to 50-fold duringmicrobial infection. It is not clear why these V gamma 2V delta2 T cells expand only after microbial infection. We show here that the stress-inducible molecule, MICA, is induced on the surface of dendritic and epithelial cells by infection with M. tuberculosis in vitro and in vivo. MICA engagement by the activating receptor, NKG2D. present on V gamma 2V delta2 T cells, resulted in a substantial enhancement of the TCR-dependent V gamma 2V delta2 T cell response to nonpeptide antigens and protein superantigens alike. Thus, a MICA-NKG2D interaction may be necessary for an effective innate immuneresponse to microbe-associated antigens that also are constitutively present in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 15:50:52