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Titolo:
Bridging the NFAT and NF-kappa B families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stress
Autore:
Lopez-Rodriguez, C; Aramburu, J; Jin, L; Rakeman, AS; Michino, M; Rao, A;
Indirizzi:
Harvard Univ, Sch Med, Ctr Blood Res, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Med, Ctr Blood Res, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 h Med, Dept Pathol, Boston, MA 02115 USA Univ Pompeu Fabra, Dept Ciences Expt & Salut, Barcelona 08003, Spain Univ Pompeu Fabra Barcelona Spain 08003 & Salut, Barcelona 08003, Spain Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA Harvard Univ Cambridge MA USA 02138 ellular Biol, Cambridge, MA 02138 USA
Titolo Testata:
IMMUNITY
fascicolo: 1, volume: 15, anno: 2001,
pagine: 47 - 58
SICI:
1074-7613(200107)15:1<47:BTNANB>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC-RENAL-FAILURE; NECROSIS-FACTOR-ALPHA; T-CELL ACTIVATION; P50 HOMODIMER; CRYSTAL-STRUCTURE; IMMUNE-RESPONSES; BETA PROMOTER; TNF-ALPHA; RECEPTOR; BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Rao, A Harvard Univ, Sch Med, Ctr Blood Res, 200 Longwood Ave, Boston, MA 02115 USA Harvard Univ 200 Longwood Ave Boston MA USA 02115 ton, MA 02115 USA
Citazione:
C. Lopez-Rodriguez et al., "Bridging the NFAT and NF-kappa B families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stress", IMMUNITY, 15(1), 2001, pp. 47-58

Abstract

The transcription factor NFAT5/TonEBP is evolutionarily the oldest member of the NFAT/Rel family of transcription factors. We show that NFAT5 is uniquely related to NF-KB and is the only member of the Rel/NFAT family to be activated by osmotic stress. Like Rel/NF-kappaB proteins but unlike the calcium-regulated NFAT proteins, NFAT5 is constitutively dimeric, and dimerization is essential for DNA binding and transcriptional activity. Using dominant-negative proteins that inhibit NFAT5 dimerization, we show that NFAT5 regulates expression of the TNF alpha and lymphotoxin-beta genes in osmotically stressed T cells. Chromatin immunoprecipitation experiments confirm thatNFAT5 binds to the TNF alpha promoter in vivo. We suggest that NFAT5 participates in specific aspects of host defense by upregulating TNF family genes and other target genes in T cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 05:01:28