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Titolo:
HLA class I and II in Lambert-Eaton myasthenic syndrome without associatedtumor
Autore:
Wirtz, PW; Roep, BO; Schreuder, GMT; van Doorn, PA; van Engelen, BGM; Kuks, JB; Twijnstra, A; de Visser, M; Visser, LH; Wokke, JH; Wintzen, AR; Verschuuren, JJ;
Indirizzi:
Leiden Univ, Med Ctr, Dept Neurol, NL-2300 RC Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands Leiden Univ, Med Ctr, Dept Immunohematol, NL-2300 RC Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands Leiden Univ, Med Ctr, Blood Bank, NL-2300 RC Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands Univ Rotterdam Hosp, Dept Neurol, Rotterdam, Netherlands Univ Rotterdam Hosp Rotterdam Netherlands eurol, Rotterdam, Netherlands Netherlands Univ Hosp, Nijmegen, Netherlands Netherlands Univ Hosp Nijmegen Netherlands Hosp, Nijmegen, Netherlands Univ Groningen Hosp, Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands Hosp, Groningen, Netherlands Netherlands Univ Hosp, Maastricht, Netherlands Netherlands Univ Hosp Maastricht Netherlands p, Maastricht, Netherlands Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands St Elisabeth Hosp, Tilburg, Netherlands St Elisabeth Hosp Tilburg Netherlands sabeth Hosp, Tilburg, Netherlands Univ Utrecht, Med Ctr, Utrecht, Netherlands Univ Utrecht Utrecht Netherlands Utrecht, Med Ctr, Utrecht, Netherlands
Titolo Testata:
HUMAN IMMUNOLOGY
fascicolo: 8, volume: 62, anno: 2001,
pagine: 809 - 813
SICI:
0198-8859(200108)62:8<809:HCIAII>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
INCREASED FREQUENCY; GRAVIS; HETEROGENEITY; GENES;
Keywords:
Lambert-Eaton myasthenic syndrome; autoimmunity; HLA; myasthenia gravis; voltage-gated calcium channel;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Wirtz, PW Leiden Univ, Med Ctr, Dept Neurol, POB 9600, NL-2300 RC Leiden, Netherlands Leiden Univ POB 9600 Leiden Netherlands NL-2300 RC Netherlands
Citazione:
P.W. Wirtz et al., "HLA class I and II in Lambert-Eaton myasthenic syndrome without associatedtumor", HUMAN IMMUN, 62(8), 2001, pp. 809-813

Abstract

Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder, in which antibodies against voltage-gated calcium channels located at nerve terminals cause muscle weakness and autonomic dysfunction. In approximately halfof the patients the autoimmune process is initiated by a tumor. In the other half of patients no tumor is found and the etiology is unknown. The aimsof this study were to investigate the strength of HLA-associations with nontumor LEMS (NT-LEMS) and to study the relation of HLA-haplotypes with age at onset of LEMS and other clinical features. Therefore, typing of FILA class I and II was performed in 19 patients with NT-LEMS, who were clinically evaluated. NT-LEMS was significantly associated with alleles of both HLA-class I (i.e. HLA-BS) as well as -class II (i.e. HLA-DR3 and -DQ2). HLA-B8+ patients had significantly younger age at onset of LEMS and tended to be female. This study shows that HLA-class I haplotype is associated with a distinct phenotype in NT-LEMS. Human Immunology 62 809-813 (2001). (C) American Society for Histocompatibility and Immunogenetics, 2001. Published by Elsevier Science Inc.

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Documento generato il 30/10/20 alle ore 09:48:03