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Titolo:
Proliferative activity of intrahepatic colorectal metastases after preoperative hemihepatic portal vein embolization
Autore:
Kokudo, N; Tada, K; Seki, M; Ohta, H; Azekura, K; Ueno, M; Ohta, K; Yamaguchi, T; Matsubara, T; Takahashi, T; Nakajima, T; Muto, T; Ikari, T; Yanagisawa, A; Kato, Y;
Indirizzi:
Canc Inst Hosp, Dept Surg, Tokyo, Japan Canc Inst Hosp Tokyo JapanCanc Inst Hosp, Dept Surg, Tokyo, Japan Canc Inst Hosp, Dept Med, Tokyo, Japan Canc Inst Hosp Tokyo JapanCanc Inst Hosp, Dept Med, Tokyo, Japan Inst Canc, Dept Pathol, Tokyo, Japan Inst Canc Tokyo JapanInst Canc, Dept Pathol, Tokyo, Japan
Titolo Testata:
HEPATOLOGY
fascicolo: 2, volume: 34, anno: 2001,
pagine: 267 - 272
SICI:
0270-9139(200108)34:2<267:PAOICM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVER METASTASES; HEPATOCYTE GROWTH; HEPATOCELLULAR-CARCINOMA; COMPUTED-TOMOGRAPHY; MAJOR HEPATECTOMY; BRANCH LIGATION; INJURED LIVER; REGENERATION; RESECTION; CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Kokudo, N Univ Tokyo, Dept Surg, Hepato Biliary Pancreat Surg Div, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan Univ Tokyo 7-3-1 Hongo Tokyo Japan 1138655 Tokyo 1138655, Japan
Citazione:
N. Kokudo et al., "Proliferative activity of intrahepatic colorectal metastases after preoperative hemihepatic portal vein embolization", HEPATOLOGY, 34(2), 2001, pp. 267-272

Abstract

Although hemihepatic portal vein embolization (PVE) has been used preoperatively to extend indications for hepatectomy in patients with colorectal metastases, the effects of this procedure on tumor growth and outcome remain controversial. To address this issue, we assessed the proliferative activity of intrahepatic metastases after PVE and the long-term outcome of this procedure. Eighteen patients with colorectal metastases underwent preoperative PVE between 1996 and 2000 (PVE group). Twenty-nine patients who underwentmajor hepatic resection without PVE served as control (non-PVE group). Thehepatic parenchymal fraction of the left lobe had significantly increased from 38.1 +/- 3.2% to 45.9 +/- 2.9% 3 weeks after PVE (+20.5%, P < .0001). Tumor volume and percent tumor volume had also significantly increased from223 +/- 89 mL to 270 +/- 97 mL (+20.8%, P = .016) and from 13.7 +/- 4.3% to 16.2 +/- 4.9% (+18.5%, P = .014), respectively. There was no apparent correlation between the increase in parenchymal volume and that in tumor volume. The Ki-67 labeling index of metastatic lesions was 46.6 +/- 7.2% in the PVE group and 35.4 +/- 12.6% in the non-PVE group (P = .013). Long-term survival was similar in the PVE and non-PVE groups, however, disease-free survival was significantly poorer in the PVE group than in the non-PVE group (P= .004). We conclude that PVE increases tumor growth and probably is associated with enhanced recurrence of disease. Although PVE is effective in extending indications for surgery, patient selection for PVE should be cautious.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/18 alle ore 07:37:16