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Titolo:
Loss of interstitial cells of Cajal and inhibitory innervation in insulin-dependent diabetes
Autore:
He, CL; Soffer, EE; Ferris, CD; Walsh, RM; Szurszewski, JH; Farrugia, G;
Indirizzi:
Mayo Clin, Dept Physiol & Biophys, Div Gastroenterol & Hepatol, Enter Neurosci Program, Rochester, MN 55905 USA Mayo Clin Rochester MN USA 55905 eurosci Program, Rochester, MN 55905 USA Cleveland Clin Fdn, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 in Fdn, Cleveland, OH 44195 USA Vanderbilt Univ, Med Ctr, Nashville, TN USA Vanderbilt Univ Nashville TN USA erbilt Univ, Med Ctr, Nashville, TN USA
Titolo Testata:
GASTROENTEROLOGY
fascicolo: 2, volume: 121, anno: 2001,
pagine: 427 - 434
SICI:
0016-5085(200108)121:2<427:LOICOC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE INTESTINAL POLYPEPTIDE; NITRIC-OXIDE SYNTHASE; GENE-RELATED PEPTIDE; PACEMAKER C-KIT; ENTERIC NERVES; GASTROINTESTINAL SYMPTOMS; HIRSCHSPRUNGS-DISEASE; MYENTERIC PLEXUS; RATS; PSEUDOOBSTRUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Farrugia, G Mayo Clin, Dept Physiol & Biophys, Div Gastroenterol & Hepatol, Enter Neurosci Program, Guggenheim 8,200 1st St SW, Rochester, MN 55905 USA Mayo Clin Guggenheim 8,200 1st St SW Rochester MN USA 55905 SA
Citazione:
C.L. He et al., "Loss of interstitial cells of Cajal and inhibitory innervation in insulin-dependent diabetes", GASTROENTY, 121(2), 2001, pp. 427-434

Abstract

Background & Aims: Gastrointestinal complications of long-standing diabetes include nausea, vomiting, abdominal pain, diarrhea, and constipation. Thepathophysiology underlying these symptoms is poorly understood. Recent evidence suggests an important role for interstitial cells of Cajal in controlling gastrointestinal motility. The aim of this study was to determine changes in interstitial cells of Cajal and enteric innervation in a patient with insulin-dependent diabetes. Methods: A full thickness jejunal biopsy was obtained from a 38-year-old insulin-dependent diabetic with evidence for diabetic gastroenteropathy. Immunohistochemistry, confocal microscopy, and 3-dimensional reconstruction techniques were used to quantify changes in the volume of interstitial cells of Cajal and enteric innervation. Results: Interstitial cells of Cajal were markedly decreased throughout the entire thickness of the jejunum. A decrease in neuronal nitric oxide synthase, vasoactive intestinal peptide, PACAP, and tyrosine hydroxylase immunopositive nerve fibers was observed in circular muscle layer while substance P immunoreactivity was increased. Conclusions: The data suggest that long-standing diabetes is associated with a decrease in interstitial cells of Cajal volume and a decrease in inhibitory innervation, associated with an increase in excitatory innervation. The changes in interstitial cells of Cajal volume and enteric nerves may underlie the pathophysiology of gastrointestinal complications associated with diabetes and suggest future therapeutic targets.

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Documento generato il 20/09/20 alle ore 03:01:12