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Titolo:
Ceruloplasmin immunoreactivity in neurodegenerative disorders
Autore:
Loeffler, DA; Sima, AAF; LeWitt, PA;
Indirizzi:
Wayne State Univ, Sch Med, Dept Immunol & Microbiol, Detroit, MI 48201 USAWayne State Univ Detroit MI USA 48201 & Microbiol, Detroit, MI 48201 USA Wayne State Univ, Sch Med, Dept Neurol, Detroit, MI 48201 USA Wayne State Univ Detroit MI USA 48201 Dept Neurol, Detroit, MI 48201 USA Wayne State Univ, Sch Med, Dept Pathol, Detroit, MI 48201 USA Wayne State Univ Detroit MI USA 48201 Dept Pathol, Detroit, MI 48201 USA Wayne State Univ, Sch Med, Dept Psychiat, Detroit, MI 48201 USA Wayne State Univ Detroit MI USA 48201 ept Psychiat, Detroit, MI 48201 USA William Beaumont Hosp, Res Inst, Dept Neurol, Royal Oak, MI 48073 USA William Beaumont Hosp Royal Oak MI USA 48073 rol, Royal Oak, MI 48073 USA
Titolo Testata:
FREE RADICAL RESEARCH
fascicolo: 2, volume: 35, anno: 2001,
pagine: 111 - 118
SICI:
1071-5762(2001)35:2<111:CIIND>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; HUNTINGTONS-DISEASE; PARKINSONS-DISEASE; ANCHORED FORM; BRAIN; ACERULOPLASMINEMIA; COPPER; IRON;
Keywords:
Alzheimer's disease; ceruloplasmin; Huntington's disease; oxidative stress; Parkinson's disease; progressive supranuclear palsy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Loeffler, DA Wayne State Univ, Sch Med, Dept Immunol & Microbiol, Detroit,MI 48201 USA Wayne State Univ Detroit MI USA 48201 Detroit, MI 48201 USA
Citazione:
D.A. Loeffler et al., "Ceruloplasmin immunoreactivity in neurodegenerative disorders", FREE RAD RE, 35(2), 2001, pp. 111-118

Abstract

Ceruloplasmin (CP) is a 132 kd cuproprotein which, together with transferrin, provides the majority of anti-oxidant capacity in serum. Increased irondeposition and lipid peroxidation in the basal ganglia of subjects with hereditary CP deficiency suggest that CP may serve as an anti-oxidant in the brain as well. The present study compared CP immunoreactivity in brain specimens from normal controls and subjects with neurodegenerative disorders (Alzheimer's disease [AD], Parkinson's disease [PD], progressive supranuclearpalsy [PSP], and Huntington's disease [HD]) (n = 5 per group). The relative intensity of neuronal CP staining and the numbers of CP-stained neurons per 25x microscope field were determined in hippocampus (CAI, subiculum, andparahippocampal gyrus), parietal cortex, frontal cortex, substantia nigra,and caudate. CP was detected in both neurons and astrocytes in all specimens, and in senile plaques and occasional neurofibrillary tangles in AD brain. Neuronal CP staining intensity tended to increase in most AD brain regions, but was statistically significant vs controls only in the CAI region ofhippocampus (p = .016). Neuronal CP staining in brain specimens from otherneurodegenerative disorders showed a slight but nonsignificant increase vscontrols. The numbers of CP-stained neurons per field did not differ between the various neurodegenerative disorders and controls. These results suggest that a modest increase in neuronal CP content is present in the AD brain, and lesser elevations in neuronal CP occur in the other neurodegenerative disorders in this study. Though CP functions as both an acute phase protein and an anti-oxidant in peripheral tissues, whether it does so in the brain remains to be determined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:37:44