Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Severe total hepatic ischemia and reperfusion: Relationship between very high alpha-tocopherol uptake and lipid peroxidation
Autore:
Giakoustidis, D; Kontos, N; Iliadis, S; Papageorgiou, G; Tsantilas, D; Spyridis, C; Papazoglou, K; Botsoglou, N; Dimitriadou, A; Giakoustidis, E;
Indirizzi:
Aristotelian Univ Thessaloniki, Hosp Hippokration, Sch Med Sci, Dept Surg,GR-54006 Salonika, Greece Aristotelian Univ Thessaloniki Salonika Greece GR-54006 Salonika, Greece Aristotelian Univ Thessaloniki, Hosp Hippokration, Sch Med Sci, Dept Biol Chem, GR-54006 Salonika, Greece Aristotelian Univ Thessaloniki Salonika Greece GR-54006 Salonika, Greece Aristotelian Univ Thessaloniki, Hosp Hippokration, Sch Vet, Dept Anim Prod, GR-54006 Salonika, Greece Aristotelian Univ Thessaloniki Salonika Greece GR-54006 Salonika, Greece
Titolo Testata:
FREE RADICAL RESEARCH
fascicolo: 2, volume: 35, anno: 2001,
pagine: 103 - 109
SICI:
1071-5762(2001)35:2<103:STHIAR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
KUPFFER CELLS; VITAMIN-E; FREE-RADICALS; LIVER; INJURY; RAT; TISSUE; HUMANS; NEUTROPHILS; MECHANISMS;
Keywords:
lipid peroxidation; malonyldialdehyde; ischemia/reperfusion; liver; alpha-tocopherol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Giakoustidis, D Aristotelian Univ Thessaloniki, Hosp Hippokration, Sch MedSci, Dept Surg,GR-54006 Salonika, Greece Aristotelian Univ Thessaloniki Salonika Greece GR-54006
Citazione:
D. Giakoustidis et al., "Severe total hepatic ischemia and reperfusion: Relationship between very high alpha-tocopherol uptake and lipid peroxidation", FREE RAD RE, 35(2), 2001, pp. 103-109

Abstract

Reperfusion injury of the liver occurs in liver transplantation and in major hepatectomies. It triggers a severe oxidative stress that leads to increased lipid peroxidation. In our study we examined the effect of parenteral supranutritional administration of alpha -tocopherol, a vitamin that plays a key role in the endogenous antioxidant system, to rats subjected to severe ischemia/reperfusion (I/R) injury of the liver. alpha -Tocopherol was administered to the animals at doses of 30 and 300mg/kg bw, whereas total hepatic ischemia was induced for 60 min followed by 120 min reperfusion. Tissueand blood samples were collected for malonyldialdehyde (MDA) and serum alpha -tocopherol assay, respectively. In the sham operation group, mean MDA level in liver was 1.14 nmole/g wet tissue in the control subgroup, and 1.01or 0.74 nmole/g wet tissue in the subgroups given 30 or 300mg/kg alpha -tocopherol. In the I/R group, mean MDA level was 1.57 nmole/g wet tissue in the control subgroup, and 0.97 and 0.77 nmole/g wet tissue in the subgroups given 30 or 300mg/kg alpha -tocopherol. Mean levels of a-tocopherol in serum (mu mole/l) were 10.20 and 1.80 in the control subgroups, 25.28 and 11.25in the subgroups treated with 30 and 300 mg/kg bw of alpha -tocopherol, and 31.00 and 13.02 in the subgroups treated with 30 and 300 mg/kg bw of alpha -tocopherol, within the sham-operation and I/R groups, respectively. A significant decrease of MDA accompanied by a significant increase of serum alpha -tocopherol was documented in the alpha -tocopherol-treated rats withinboth groups. Ischemia/reperfusion triggered a significant increase of the MDA level in the liver of the rats not treated with alpha -tocopherol as compares with the treated animals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:08:47