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Titolo:
The mechanisms for nitration and nitrotyrosine formation in vitro and in vivo: Impact of diet
Autore:
Oldreive, C; Rice-Evans, C;
Indirizzi:
Univ London Kings Coll, Guys Kings & St Thomas Sch Biomed Sci, Wolfson CtrAge Related Dis, London SE1 9RT, England Univ London Kings Coll London England SE1 9RT s, London SE1 9RT, England
Titolo Testata:
FREE RADICAL RESEARCH
fascicolo: 3, volume: 35, anno: 2001,
pagine: 215 - 231
SICI:
1071-5762(2001)35:3<215:TMFNAN>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; AMYOTROPHIC-LATERAL-SCLEROSIS; MANGANESE-SUPEROXIDE-DISMUTASE; DEPENDENT TYROSINE NITRATION; LOW-DENSITY-LIPOPROTEIN; N-NITROSO COMPOUNDS; HUMAN ATHEROSCLEROTIC LESIONS; GASTRIC-CANCER PATIENTS; CENTRAL-NERVOUS-SYSTEM; SURFACTANT PROTEIN-A;
Keywords:
nitrotyrosine; nitrate; nitrite; peroxynitrite; nitric oxide; nitration; reactive nitrogen species;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
212
Recensione:
Indirizzi per estratti:
Indirizzo: Rice-Evans, C Univ London Kings Coll, Guys Kings & St Thomas Sch Biomed Sci, Wolfson CtrAge Related Dis, London SE1 9RT, England Univ London Kings Coll London England SE1 9RT 9RT, England
Citazione:
C. Oldreive e C. Rice-Evans, "The mechanisms for nitration and nitrotyrosine formation in vitro and in vivo: Impact of diet", FREE RAD RE, 35(3), 2001, pp. 215-231

Abstract

The detection of 3-nitro-L-tyrosine residues associated with many disease states, including gastric cancer, has implicated a role for peroxynitrite in vivo, and thus endogenously produced nitric oxide and superoxide. Additionally, dietary nitrate has been suggested to be involved in the pathogenesis of gastric cancer through a mechanism involving reduction to nitrite and subsequent formation of potentially mutagenic nitrosocompounds. Studies have now demonstrated that a multitude of reactive nitrogen species other thanperoxynitrite are capable of producing nitrotyrosine. Thus, we have reviewed the evidence that dietary nitrate, amongst other reactive nitrogen species, may contribute to the body burden of nitrotyrosine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:28:12