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Titolo:
Flavonoids protect mice from two types of lethal shock induced by endotoxin
Autore:
Takahashi, K; Morikawa, A; Kato, Y; Sugiyama, T; Koide, N; Mu, MM; Yoshida, T; Yokochi, T;
Indirizzi:
Aichi Med Univ, Sch Med, Dept Microbiol & Immunol, Aichi 4801195, Japan Aichi Med Univ Aichi Japan 4801195 obiol & Immunol, Aichi 4801195, Japan Aichi Med Univ, Sch Med, Res Ctr Infect Dis, Div Bacterial Toxin, Aichi 4801195, Japan Aichi Med Univ Aichi Japan 4801195 Bacterial Toxin, Aichi 4801195, Japan
Titolo Testata:
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
fascicolo: 1, volume: 31, anno: 2001,
pagine: 29 - 33
SICI:
0928-8244(200107)31:1<29:FPMFTT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE PRODUCTION; NF-KAPPA-B; SEPTIC SHOCK; LIPOPOLYSACCHARIDE; MACROPHAGES; STRATEGIES; ACTIVATION; RAW-264.7; SILYMARIN; BAICALEIN;
Keywords:
flavonoid; lipopolysaccharide; endotoxin; endotoxic shock; anti-oxidant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Yokochi, T Aichi Med Univ, Sch Med, Dept Microbiol & Immunol, Aichi 4801195, Japan Aichi Med Univ Aichi Japan 4801195 unol, Aichi 4801195, Japan
Citazione:
K. Takahashi et al., "Flavonoids protect mice from two types of lethal shock induced by endotoxin", FEMS IM MED, 31(1), 2001, pp. 29-33

Abstract

The protective effect of flavonoids on two types of lethal endotoxic shockwas studied. A lethal endotoxic shock was induced by administration of lipopolysaccharide (LPS) into D-galactosamine (D-GalN)-sensitized mice and another one was done by administration of a high dose of LPS into normal mice. Pretreatment with a series of flavonoids protected mice from two types of endotoxin lethality. Flavonoid pretreatment reduced the serum tumor necrosis factor-alpha (TNF-alpha.) level in mice injected with D-GalN and LPS, butnot in mice injected with a high dose of LPS. TNF-alpha -induced lethal shock in D-GalN-sensitized mice was also protected by pretreatment with flavonoids, suggesting that flavonoids augmented the resistance to TNF-alpha lethality. On the other hand, flavonoids reduced the plasma level of lipid peroxides in mice injected with a high dose of LPS, but not in D-GalN-sensitized mice. Taken together, these results indicated that flavonoids might protect mice from two types of endotoxin lethality. The protective mechanism offlavonoids in each endotoxin lethality is discussed. (C) 2001 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:27:55