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Titolo:
Association of immunological disorders in lethal side effect of NSAIDs on beta-glucan-administered mice
Autore:
Takahashi, H; Ohno, N; Adachi, Y; Yadomae, T;
Indirizzi:
Tokyo Univ Pharm & Life Sci, Sch Pharm, Lab Immunopharmacol Microbial Prod, Tokyo 1920392, Japan Tokyo Univ Pharm & Life Sci Tokyo Japan 1920392 od, Tokyo 1920392, Japan
Titolo Testata:
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
fascicolo: 1, volume: 31, anno: 2001,
pagine: 1 - 14
SICI:
0928-8244(200107)31:1<1:AOIDIL>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ASPIRIN-SENSITIVE ASTHMA; BACTERIAL LIPOPOLYSACCHARIDE; PHOSPHOLIPASE A(2); FACTOR-ALPHA; CYCLOOXYGENASE-2; INDOMETHACIN; EXPRESSION; GENE; MACROPHAGES;
Keywords:
beta-glucan; indomethacin; lethal toxicity; non-steroidal anti-inflammatory drug; nabumetone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Ohno, N Tokyo Univ Pharm & Life Sci, Sch Pharm, Lab Immunopharmacol Microbial Prod, 1432-1 Horinouchi, Tokyo 1920392, Japan Tokyo Univ Pharm & Life Sci 1432-1 Horinouchi Tokyo Japan 1920392
Citazione:
H. Takahashi et al., "Association of immunological disorders in lethal side effect of NSAIDs on beta-glucan-administered mice", FEMS IM MED, 31(1), 2001, pp. 1-14

Abstract

(1 --> 3)-beta -D-Glucan (beta -glucan) is a biological response modifier that regulates host immune response. We have found that the combination of a beta -glucan and a non-steroidal anti-inflammatory drug (NSAID), indomethacin (IND), induced lethal toxicity in mice [Yoshioka et al. (1998) FEMS Immunol. Med. Microbiol., 21, 171-179]. This study was undertaken to analyze the mechanism of the lethal side effect. Combination of a beta -glucan and IND increased the number of leukocytes, especially macrophages and neutrophils, in various organs and these cells were activated. The activated state of these cells was supported by the enhanced production of interferon-gammain the presence of IND in vitro culture of the peritoneal exudate cells. Intestinal bacterial flora was translocated into the peritoneal cavity in these mice to cause peritonitis. Comparing the toxicity of various NSAIDs, nabumetone, a partially cyclooxygenase-2-selective NSAID with weaker toxicityto the gastrointestinal tract, did not exhibit a lethal side effect. Thesefacts strongly suggested that gastrointestinal damage by NISAIDs was more severe in beta -glucan-administered mice, resulting in peritonitis by enteric bacteria and leading to death. (C) 2001 Federation of European Microbiological Societies. Published by Elsevier Science BN. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:08:33