Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Peroxisome proliferator-activated receptor alpha-responsive genes induced in the newborn but not prenatal liver of peroxisomal fatty acyl-CoA oxidasenull mice
Autore:
Cook, WS; Jain, S; Jia, Y; Cao, WQ; Yeldandi, AV; Reddy, JK; Rao, MS;
Indirizzi:
Northwestern Univ, Sch Med, Dept Pathol, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 Dept Pathol, Chicago, IL 60611 USA
Titolo Testata:
EXPERIMENTAL CELL RESEARCH
fascicolo: 1, volume: 268, anno: 2001,
pagine: 70 - 76
SICI:
0014-4827(20010801)268:1<70:PPRAGI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-LIVER; BETA-OXIDATION; DIFFERENTIAL EXPRESSION; CDNA CLONING; CLOFIBRATE; ENZYMES; FAMILY; ACID; METABOLISM; INDUCTION;
Keywords:
PPAR alpha; peroxisomes; acyl-CoA oxidase-deficient mice; beta-oxidation; developmental regulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Rao, MS Northwestern Univ, Sch Med, Dept Pathol, 303 E Chicago Ave, Chicago, IL 60611 USA Northwestern Univ 303 E Chicago Ave Chicago IL USA 60611 60611 USA
Citazione:
W.S. Cook et al., "Peroxisome proliferator-activated receptor alpha-responsive genes induced in the newborn but not prenatal liver of peroxisomal fatty acyl-CoA oxidasenull mice", EXP CELL RE, 268(1), 2001, pp. 70-76

Abstract

Mice deficient in fatty acyl-CoA oxidase (AOX(-/-)), the first enzyme of the peroxisomal beta -oxidation system, develop specific morphological and molecular changes in the liver characterized by microvesicular fatty change,increased mitosis, spontaneous peroxisome proliferation, increased m-RNA and protein levels of genes regulated by peroxisome proliferator-activated receptor alpha (PPAR alpha), and hepatocellular carcinoma. Based on these findings it is proposed that substrates for AOX function as ligands for PPAR alpha. In this study we examined the sequential changes in morphology and gene expression in the liver of wild-type and AOX(-/-) mice at Embryonic Day17.5, and during postnatal development up to 2 months of age. In AOX(-/-) mice high levels of expression of PPAR alpha -responsive genes in the livercommenced on the day of birth and persisted throughout the postnatal period. We found no indication of PPAR alpha activation in the livers of AOX(-/-) mice at embryonic age E17.5. In AOX(-/-) mice microvesicular fatty changein liver cells was evident at 7 days. At 2 months of age livers showed extensive steatosis and the presence in the periportal areas of clusters of hepatocytes with abundant granular eosinophilic cytoplasm rich in peroxisomes. These results suggest that the biological ligands for PPAR alpha vis a vis substrates for AOX either are not functional in fetal liver or do not cross the placental barrier during the fetal development and that postnatally they are likely derived from milk and diet. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 01:24:25