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Titolo:
Human leukocyte antigen genes may outweigh racial background when generating a specific immune response in sarcoidosis
Autore:
Grunewald, J; Eklund, A;
Indirizzi:
Karolinska Hosp, Lung Res Lab L2 01, Dept Med, Div Resp Med, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 Med, S-17176 Stockholm, Sweden
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 5, volume: 17, anno: 2001,
pagine: 1046 - 1048
SICI:
0903-1936(200105)17:5<1046:HLAGMO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL RECEPTOR; BRONCHOALVEOLAR LAVAGE FLUID; CONVERTING ENZYME GENE; PULMONARY SARCOIDOSIS; PERIPHERAL-BLOOD; LYMPHOCYTES-T; POLYMORPHISM; USAGE; ALPHA; CD4+;
Keywords:
genetic basis of disease; human leukocyte antigen; immunology; interstitial lung disease; sarcoidosis; T-cell receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Grunewald, J Karolinska Hosp, Lung Res Lab L2 01, Dept Med, Div Resp Med, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 Stockholm, Sweden
Citazione:
J. Grunewald e A. Eklund, "Human leukocyte antigen genes may outweigh racial background when generating a specific immune response in sarcoidosis", EUR RESP J, 17(5), 2001, pp. 1046-1048

Abstract

Presented is a sarcoidosis patient of African origin, who was adopted at an early age and grew up in Sweden. This patient displayed an immune response identical to that previously reported in human leukocyte antigen (HLA)-DR17 positive Caucasian sarcoidosis patients in Scandinavia, with T-cell receptor AV2S3+ T-cells accumulating in the lungs. HLA typing also established that she was DR17 positive, which is a rare HLA type for individuals of African origin. To the authors' knowledge, this specific immune response has not previously been reported in patients of African origin. Moreover, the clinical manifestations of sarcoidosis were similar to those known to be strongly linked to HLA-DR17 in Scandinavians, i.e. with Lofgren's syndrome. The case presented here suggests certain human leukocyte antigen genes to be strongly linked to specific immune responses that are identical irrespective of the racial background. If such an immune response were important for the subsequent clinical manifestations, this case would argue for the importance of human leukocyte antigen genes in the genetic predisposition to sarcoidosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 05:51:32