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Titolo:
Eotaxin and monocyte chemoattractant protein-1 in chronic eosinophilic pneumonia
Autore:
Tateno, H; Nakamura, H; Minematsu, N; Amakawa, K; Terashima, T; Fujishima, S; Luster, AD; Lilly, CM; Yamaguchi, K;
Indirizzi:
Keio Univ, Sch Med, Dept Med, Cardiopulm Div,Shinjuku ku, Tokyo 1608582, Japan Keio Univ Tokyo Japan 1608582 pulm Div,Shinjuku ku, Tokyo 1608582, Japan Harvard Univ, Sch Med, Brigham & Womens Hosp, Boston, MA USA Harvard UnivBoston MA USA ch Med, Brigham & Womens Hosp, Boston, MA USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Boston, MA USA Harvard Univ Boston MA USA h Med, Massachusetts Gen Hosp, Boston, MA USA
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 5, volume: 17, anno: 2001,
pagine: 962 - 968
SICI:
0903-1936(200105)17:5<962:EAMCPI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED T-CELLS; BRONCHOALVEOLAR LAVAGE; ALLERGIC INFLAMMATION; AIRWAY HYPERRESPONSIVENESS; LUNG-DISEASES; CHEMOKINES; EXPRESSION; CYTOKINES; IL-5; ASTHMA;
Keywords:
bronchoalveolar lavage; chronic eosinophilic pneumonia; eotaxin; interleukin-5; interstitial lung disease; monocyte chemoattractant protein-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Nakamura, H Keio Univ, Sch Med, Dept Med, Cardiopulm Div,Shinjuku ku, 35 Shinanomachi,Tokyo 1608582, Japan Keio Univ 35 Shinanomachi Tokyo Japan 1608582 1608582, Japan
Citazione:
H. Tateno et al., "Eotaxin and monocyte chemoattractant protein-1 in chronic eosinophilic pneumonia", EUR RESP J, 17(5), 2001, pp. 962-968

Abstract

Chronic eosinophilic pneumonia (CEP) is characterized by chronic or recurrent pulmonary infiltrates with eosinophils, but the precise mechanism of eosinophil accumulation has not been fully elucidated. Eotaxin is one of the CC chemokines that selectively recruits eosinophils and contributes to the pathogenesis of allergic airway diseases including asthma, but its roles inpathogenesis of CEP have not been fully elucidated. The authors measured concentrations of eotaxin and other CC chemokines monocyte chemoattractant protein-1 (MCP-1), regulated on activation, normal T-cell expressed and secreted, macrophage inflammatory protein-la, and the eosinophil activating Th2 cytokine interleukin (IL)-5 in bronchoalveolar lavage (BAL) fluid from CEP patients (n=11), and compared these concentrations with those from control subjects (n=6). The eotaxin (904 +/- 203 versus 29 +/-7 pg.mL(-1), p=0.0001), MCP-1 (194 +/- 57 versus 15 +/-2 pg.mL(-1), p <0.05), and IL-5 (7.8 +/-2.0 versus 2.7 +/-0.6 pg.mL(-1), p <6.05) levels,were significantly higher for cases with CEP in comparison to those serving as controls. Proportions of eosinophil and lymphocyte counts were greater in BAL fluid from CEP patients. Eotaxin and IL-5 levels correlated with the proportion of eosinophils in BAL fluid from CEP patients. MCP-I correlated with the relative lymphocyte numbers. In short, eotaxin, interleukin-5, and monocyte chemoattractant protein-1 levels were higher in the BAL fluid of CEP patients and these levels may contribute to eosinophil and lymphocyte recruitment and activation in the airways as found with this disorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 13:12:47