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Titolo:
The feasibility of airways hyperresponsiveness as an inclusion criterion for studies on childhood asthma
Autore:
Kamps, AWA; Visser, MJ; de Vries, TW; van Aalderen, WMC; Postma, DS; Brand, RLP;
Indirizzi:
Univ Groningen Hosp, Dept Pulmonol, NL-9713 EZ Groningen, Netherlands UnivGroningen Hosp Groningen Netherlands NL-9713 EZ ningen, Netherlands Med Ctr, Dept Pediat, Leeuwarden, Netherlands Med Ctr Leeuwarden Netherlands tr, Dept Pediat, Leeuwarden, Netherlands Emma Childrens Hosp, Dept Pediat, Amsterdam, Netherlands Emma Childrens Hosp Amsterdam Netherlands ediat, Amsterdam, Netherlands
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 5, volume: 17, anno: 2001,
pagine: 887 - 891
SICI:
0903-1936(200105)17:5<887:TFOAHA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM TREATMENT; LUNG-FUNCTION; BRONCHIAL RESPONSIVENESS; INHALED CORTICOSTEROIDS; CHILDREN; SYMPTOMS; METHACHOLINE; ATOPY; LIFE;
Keywords:
airway hyperresponsiveness; childhood asthma; inclusion criterion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Brand, RLP Weezenlanden Hosp, Isala Klinieken, Dept Pediat, POB 10500, NL-8000 GM Zwolle, Netherlands Weezenlanden Hosp POB 10500 Zwolle NetherlandsNL-8000 GM ands
Citazione:
A.W.A. Kamps et al., "The feasibility of airways hyperresponsiveness as an inclusion criterion for studies on childhood asthma", EUR RESP J, 17(5), 2001, pp. 887-891

Abstract

The feasibility of moderately severe airway hyperresponsiveness (AH) was examined as an inclusion criterion for clinical trials in asthmatic children. During the baseline period of a long-term clinical trial in asthmatic children, maintenance therapy with fluticasone (200 mug(.)day(-1)) was stoppedfor a maximum of 8 weeks and methacholine challenges were performed at 2-week intervals or earlier if the patients' condition deteriorated. Patients were eligible to continue the study if the provocative dose of methacholinecausing a 20% fall in forced expired volume in one second (FEV1) (PD20) was < 80 mug. Fifty-one per cent of the children did not develop a PD20 < 80 mug after withdrawal of fluticasone. Patients with or without a PD20 < 80 mug did not differ in duration of asthma, duration of treatment, or peak flow variation. Patients with a PD20 < 80 mug had higher levels of total and specific immunoglobulin-E, and lower levels of FEV1 and mean maximal expiratory flow than patients with a PD20 greater than or equal to 80 mug. Forty-four per cent of the patients with a PD20 greater than or equal to 80 mug did not have any symptoms during the wash-out period and 39% of these patients remained free from symptoms during one year followup. The results of thisstudy suggest that recruiting asthmatic children for clinical trials may be difficult if airways hyperresponsiveness is used as the sole inclusion criterion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/02/20 alle ore 00:20:42