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Titolo:
Comparison of apomorphine, amphetamine and dizocilpine disruptions of prepulse inhibition in inbred and outbred mice strains
Autore:
Varty, GB; Walters, N; Cohen-Williams, M; Carey, GJ;
Indirizzi:
Schering Plough Res Inst, CNS, CV Biol Res, Kenilworth, NJ 07033 USA Schering Plough Res Inst Kenilworth NJ USA 07033 Kenilworth, NJ 07033 USA
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 424, anno: 2001,
pagine: 27 - 36
SICI:
0014-2999(20010713)424:1<27:COAAAD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHENCYCLIDINE-INDUCED DEFICITS; STARTLE RESPONSE; SCHIZOPHRENIC-PATIENTS; ACOUSTIC STARTLE; MOUSE STRAINS; RAT STRAINS; REFLEX; HABITUATION;
Keywords:
acoustic startle response; prepulse inhibition; schizophrenia; (mouse strain); apomorphine; amphetamine; dizocilpine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Varty, GB Schering Plough Res Inst, CNS, CV Biol Res, K-15-2-2600,2015 Galloping Hill Rd, Kenilworth, NJ 07033 USA Schering Plough Res Inst K-15-2-2600,2015 Galloping Hill Rd Kenilworth NJ USA 07033
Citazione:
G.B. Varty et al., "Comparison of apomorphine, amphetamine and dizocilpine disruptions of prepulse inhibition in inbred and outbred mice strains", EUR J PHARM, 424(1), 2001, pp. 27-36

Abstract

The dopamine agonist apomorphine robustly disrupts prepulse inhibition of the acoustic startle response in the rat, yet published studies have not demonstrated a robust disruption of prepulse inhibition with apomorphine in the mouse. The aim of these studies was to establish the optimal prepulse conditions (using manipulations to prepulse intensity and inter-stimulus interval) and mouse strain(s) for testing apomorphine, and also the prepulse inhibition disrupting drugs amphetamine, and dizocilpine (NIK-801). The effects of these drugs on startle response and prepulse inhibition were tested in outbred CD-1 and Swiss Webster (CFW) strains, and the inbred C57BL/6, 129X1/SvJ, and A/J strains. There were strain differences with baseline startle and prepulse inhibition in that the CD-1, CFW, and C57BL/6 strains exhibited high levels of startle and prepulse inhibition, the 129X1/SvJ strain exhibited low levels of startle but high levels of prepulse inhibition, whilethe A/J strain exhibited low startle and no prepulse inhibition. Apomorphine disrupted prepulse inhibition in the CFW and C57BL/6 strains and the effect was only evident when using a short 30 ms inter-stimulus interval. Amphetamine disrupted prepulse inhibition in the CFW. C57BL/6, and 129X1/SvJ strains, and dizocilpine disrupted prepulse inhibition in the CD-1, CFW, C57BL/6, and 129X1/SvJ strains. The effects of amphetamine and dizocilpine wereindependent of the inter-stimulus interval. These studies demonstrated clear strain differences in the startle response and prepulse inhibition, and the pharmacological disruptions of prepulse inhibition, and suggest that inter-stimulus intervals less than 100 ms may be optimal for detecting the effects of apomorphine in mice. (C) 2001 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:49:45