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Titolo:
Levels of dopamine in blood and brain following nasal administration to rats
Autore:
Dahlin, M; Jansson, B; Bjork, E;
Indirizzi:
Uppsala Univ, Biomed Ctr, Div Pharmaceut, Dept Pharm, SE-75123 Uppsala, Sweden Uppsala Univ Uppsala Sweden SE-75123 ept Pharm, SE-75123 Uppsala, Sweden
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
fascicolo: 1, volume: 14, anno: 2001,
pagine: 75 - 80
SICI:
0928-0987(200108)14:1<75:LODIBA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; OLFACTORY PATHWAY; DELIVERY; CAVITY; ROUTE; MICE; ENHANCEMENT; PHYSIOLOGY; TRANSPORT; COCAINE;
Keywords:
nasal administrations; dopamine; rat; olfactory pathway; cerebrospinal fluid (CSF); brain targeting;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Bjork, E Uppsala Univ, Biomed Ctr, Div Pharmaceut, Dept Pharm, Box 580, SE-75123 Uppsala, Sweden Uppsala Univ Box 580 Uppsala Sweden SE-75123 123 Uppsala, Sweden
Citazione:
M. Dahlin et al., "Levels of dopamine in blood and brain following nasal administration to rats", EUR J PH SC, 14(1), 2001, pp. 75-80

Abstract

The aim of this study was to investigate the levels of [H-3]dopamine in blood, the cerebrospinal fluid (CSF) and brain tissue samples in rats and to find out whether the drug is transferred along the olfactory pathway to thecentral nervous system following nasal administration. [3(H)]Dopamine (50 mu Ci) was given to male Sprague-Dawley rats either intravenously or nasally to the right nostril, For the absorption study, blood samples were withdrawn from the carotid artery. The CSF samples were taken by cisternal puncture and then brain tissue samples were excised. The presence of unchanged dopamine in the samples was ascertained using thin layer chromatography (TLC). The radioactivity in the samples was measured using liquid scintillation. The greatest amount of the total radioactivity absorbed from the nasal mucosa into the systemic circulation was observed at the first sampling point 15 min after administration. The bioavailability of the total radioactivitywas 68 +/- 30%. The uptake of A [H-3]dopamine in the brain was significantly higher 30 min after nasal administration than after intravenous administration (P<0.01). TLC data showed that approximately 59%, 14% and 68% of theradioactivity in the olfactory bulb, CSF and olfactory mucosa, respectively, coeluted with dopamine. In conclusion, these results show that unchangeddopamine is transferred into the olfactory bulb via the olfactory pathway in rats. (c) 2001 Elsevier Science BY. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 22:36:11