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Titolo:
Gonadotropin-releasing hormone antagonist protocol: a novel method of ovarian stimulation in poor responders
Autore:
Nikolettos, N; Al-Hasani, S; Felberbaum, R; Demirel, LC; Kupker, W; Montzka, P; Xia, YX; Schopper, B; Sturm, R; Diedrich, K;
Indirizzi:
Med Univ Lubeck, Dept Obstet Gynecol, D-23538 Lubeck, Germany Med Univ Lubeck Lubeck Germany D-23538 Gynecol, D-23538 Lubeck, Germany
Titolo Testata:
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
fascicolo: 2, volume: 97, anno: 2001,
pagine: 202 - 207
SICI:
0301-2115(200108)97:2<202:GHAPAN>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO FERTILIZATION; HUMAN MENOPAUSAL GONADOTROPIN; INTRACYTOPLASMIC SPERM INJECTION; EMBRYO TRANSFER PROGRAM; INVITRO FERTILIZATION; LUTEINIZING-HORMONE; FOLLICULAR PHASE; GNRH ANTAGONIST; CETRORELIX; AGONIST;
Keywords:
poor response; GnRH agonist; GnRH antagonist; intracytoplasmic sperm injection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Al-Hasani, S Med Univ Lubeck, Dept Obstet Gynecol, Ratzeburger Allee 160, D-23538 Lubeck, Germany Med Univ Lubeck Ratzeburger Allee 160 Lubeck Germany D-23538
Citazione:
N. Nikolettos et al., "Gonadotropin-releasing hormone antagonist protocol: a novel method of ovarian stimulation in poor responders", EUR J OB GY, 97(2), 2001, pp. 202-207

Abstract

Objective: To estimate the efficacy of gonadotropin-releasing hormone (GnRH) antagonist 'Cetrorelix' in poor responders comparing with the standard long protocol. Design: The study population consisted of 21 poor responders who underwent ICSI and treated with Cetrorelix according to the multiple-dose protocol and who were compared with 21 poor responders treated accordingto the long protocol and who also underwent ICSI Patients in both groups were matched for chronological age, the number of follicles found by ultrasound at the retrieval day and cause of infertility. Fifteen patients of GnRHantagonist group were treated with the combination of GnRH antagonist withclomiphene citrate (CC) plus gonadotropins, while six patients were treated with the combination of GnRH antagonist plus gonadotropins, but without CC. Results: The use of GnRH antagonist in a multiple dose protocol gave a pregnancy rate of 14.28% which vas in the range expected for patient with poor response, but with shorter treatment duration and with fewer ampoules ofgonadotropins as compared with the use of a GnRH agonist protocol in a depot formulation. Within Cetrorelix group patients who received CC had a significant shorter duration of stimulation and needed fewer ampoules as compared with patients in the same group who did not receive CC. Conclusions: A GnRH antagonist multiple dose protocol may be the protocol of choice for thetreatment of poor responders. The use of GnRH antagonist Cetrorelix ended with significantly less ampoules of gonadotropins and a shorter duration ofstimulation. (C) 2001 Elsevier Science Ireland Ltd, All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:52:57