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Titolo:
Comparison of Tc-99m-sestamibi lung/heart ratio, transient ischaemic dilation and perfusion defect size for the identification of severe and extensive coronary artery disease
Autore:
Romanens, M; Gradel, C; Saner, H; Pfisterer, M;
Indirizzi:
Univ Hosp Kantonspital, Div Cardiol, CH-4031 Basel, Switzerland Univ Hosp Kantonspital Basel Switzerland CH-4031 4031 Basel, Switzerland Rodiag Grp, Inst Radiol, Olten, Switzerland Rodiag Grp Olten Switzerland odiag Grp, Inst Radiol, Olten, Switzerland Cantonal Hosp Olten, Olten, Switzerland Cantonal Hosp Olten Olten Switzerland al Hosp Olten, Olten, Switzerland
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 7, volume: 28, anno: 2001,
pagine: 907 - 910
SICI:
0340-6997(200107)28:7<907:COTLRT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR FUNCTION; LUNG UPTAKE; SESTAMIBI; EXERCISE; WASHOUT; IMAGES; SPECT;
Keywords:
severe coronary artery disease; scintigraphy; lung/heart ratio; transient ischaemic dilation ratio;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Pfisterer, M Univ Hosp Kantonspital, Div Cardiol, CH-4031 Basel, Switzerland Univ Hosp Kantonspital Basel Switzerland CH-4031 witzerland
Citazione:
M. Romanens et al., "Comparison of Tc-99m-sestamibi lung/heart ratio, transient ischaemic dilation and perfusion defect size for the identification of severe and extensive coronary artery disease", EUR J NUCL, 28(7), 2001, pp. 907-910

Abstract

The ability to identify patients with severe coronary artery disease (CAD)by analysis of perfusion defects is limited. The lung/heart ratio (LHR) and transient ischaemic dilatation (TID) have been used for this purpose in thallium-201 scintigraphy. The value of these parameters in technetium-99m sestamibi single-photon emission tomography (SPET) imaging is controversial. In this study, therefore, we determined TID and LHR in a single-day rest/stress Tc-99m-sestamibi SPET perfusion protocol and compared these measurements with perfusion defect size (PDS) and angiographic severity of CAD. Severe CAD was defined as > 75% left main coronary stenosis and/or > 90% proximal left anterior descending artery stenosis and/or >90% proximal stenosis in the left circumflex and right coronary arteries. LHR was determined from a stress anterior planar image recorded less than or equal to6 min after exercise. TID ratio was derived from automatically calculated left ventricular rest/stress volumes, and PDS was measured based on semi-automated computer software (CEqual). Diagnostic accuracy and predictive values were compared between 22 patients with severe and 98 patients without severe CAD. LHRs showed a higher sensitivity (73%) for the assessment of severe CAD as compared to PDS and TID ratio (41% and 23% respectively, P <0.01), whereas specificity was highest for TID ratio [95%, P<0.01 when compared to PDS (84%) and LHR (82%)]. It is concluded that increased LHR in 99mTc-sestamibi myocardial perfusion imaging seems to yield good diagnostic accuracy in the detection of patients with severe CAD and may be derived from a single-day rest/stress study.

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Documento generato il 28/03/20 alle ore 23:38:17