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Titolo:
3-[I-123]Iodo-alpha-methyl-L-tyrosine uptake in cerebral gliomas: relationship to histological grading and prognosis
Autore:
Schmidt, D; Gottwald, U; Langen, KJ; Weber, F; Hertel, A; Floeth, F; Felsberg, J; Reifenberger, G; Coenen, HH; Muller-Gartner, HW;
Indirizzi:
Res Ctr Julich GmbH, Inst Med, D-52425 Julich, Germany Res Ctr Julich GmbH Julich Germany D-52425 Med, D-52425 Julich, Germany Univ Dusseldorf, Clin Nucl Med, D-40001 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40001 , D-40001 Dusseldorf, Germany Univ Dusseldorf, Clin Neurosurg, D-40001 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40001 , D-40001 Dusseldorf, Germany Univ Dusseldorf, Inst Nueropathol, D-40001 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40001 , D-40001 Dusseldorf, Germany Res Ctr Julich GmbH, Inst Nucl Chem, D-52425 Julich, Germany Res Ctr Julich GmbH Julich Germany D-52425 Chem, D-52425 Julich, Germany
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 7, volume: 28, anno: 2001,
pagine: 855 - 861
SICI:
0340-6997(200107)28:7<855:3UICGR>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; ALPHA-METHYL-TYROSINE; AMINO-ACID-TRANSPORT; BRAIN-TUMORS; IODINE-123-ALPHA-METHYL TYROSINE; L-<1-C-11>TYROSINE PET; COMPUTED-TOMOGRAPHY; METHIONINE UPTAKE; C-11 METHIONINE; GA-68 EDTA;
Keywords:
amino acids; 3-[I-123]Iodo-alpha-methyl-L-tyrosine; cerebral gliomas; histological grading; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Langen, KJ Res Ctr Julich GmbH, Inst Med, D-52425 Julich, Germany Res Ctr Julich GmbH Julich Germany D-52425 25 Julich, Germany
Citazione:
D. Schmidt et al., "3-[I-123]Iodo-alpha-methyl-L-tyrosine uptake in cerebral gliomas: relationship to histological grading and prognosis", EUR J NUCL, 28(7), 2001, pp. 855-861

Abstract

3-[I-123]Iodo-alpha -methyl-L-tyrosine (IMT) is employed clinically as a tracer of amino acid transport in brain tumours using single-photon emissiontomography (SPET). This study investigates the role of IMT SPET in the non-invasive histological grading and prognostic evaluation of cerebral gliomas. The files of patients investigated by IMT SPET in our clinic between 1988 and 1996 were evaluated retrospectively. Complete followup was available for 58 patients with cerebral gliomas investigated by IMT SPET shortly after tumour diagnosis. Seventeen patients had low-grade gliomas (WHO grade II), 14 had anaplastic gliomas (WHO grade III) and 27 had glioblastomas (WHO grade IV). Thirty-six cases were primary tumours and 22 cases, recurrences. Maximal and mean tumour-to-brain (T/B) ratios of IMT uptake at the first IMT SPET investigation were related to histological grading and survival time. Patients with low-grade gliomas showed significantly longer survival thanpatients with high-grade (grade III or IV) tumours. Gliomas without contrast enhancement on computed tomography or magnetic resonance imaging scans were associated with longer patient survival than tumours with contrast enhancement. The T/B ratios of IMT SPET showed no differences in relation to histological grading [WHO grade II: 1.73 +/-0.59; WHO grade III: 1.74 +/-0.38; WHO grade IV: 1.59 +/-0.35, (mean SD, T/B ratios of mean tumour uptake)]. The median survival time of patients with a high T/B ratio on IMT SPET wasnot significantly different from that of patients with a low T/B ratio (T/B ratio <1.6, 14.8 months; T/B ratio greater than or equal to1.6, 13.0 months). Thus, no evidence could be found for a relationship between IMT uptakein cerebral gliomas and either histological grading or survival time. Nevertheless, IMT SPET constitutes a useful method for the detection of primaryand recurrent gliomas, determination of tumour extent and individual follow-up.

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Documento generato il 24/01/21 alle ore 04:42:55