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Titolo:
Biodistribution of [C-11]methylaminoisobutyric acid, a tracer for PET studies on system A amino acid transport in vivo
Autore:
Sutinen, E; Jyrkkio, S; Gronroos, T; Haaparanta, M; Lehikoinen, P; Nagren, K;
Indirizzi:
Univ Turku, Cent Hosp, Dept Radiotherapy, FIN-20521 Turku, Finland Univ Turku Turku Finland FIN-20521 adiotherapy, FIN-20521 Turku, Finland Univ Turku, PET, Turku Ctr, Cent Hosp, FIN-20521 Turku, Finland Univ Turku Turku Finland FIN-20521 , Cent Hosp, FIN-20521 Turku, Finland Univ Turku, Dept Oncol, Cent Hosp, FIN-20521 Turku, Finland Univ Turku Turku Finland FIN-20521 , Cent Hosp, FIN-20521 Turku, Finland
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 7, volume: 28, anno: 2001,
pagine: 847 - 854
SICI:
0340-6997(200107)28:7<847:BO[AAT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-AMINOISOBUTYRIC-ACID; CANCER CACHEXIA; MOLECULAR-BIOLOGY; MAMMALIAN-CELLS; TUMOR-DETECTION; ANIMAL-CELLS; METABOLISM; PLASMA; INSULIN; GLUCOSE;
Keywords:
carbon-11-methylaminoisobutyric acid; system A amino acid transport; PET; rat; human;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Sutinen, E Univ Turku, Cent Hosp, Dept Radiotherapy, POB 52, FIN-20521 Turku, Finland Univ Turku POB 52 Turku Finland FIN-20521 20521 Turku, Finland
Citazione:
E. Sutinen et al., "Biodistribution of [C-11]methylaminoisobutyric acid, a tracer for PET studies on system A amino acid transport in vivo", EUR J NUCL, 28(7), 2001, pp. 847-854

Abstract

[N-methyl-C-11]alpha -Methylaminoisobutyric acid (C-11-MeAIB) is a potentially useful tracer for positron emission tomography (PET) studies on hormonally regulated system A amino acid transport. C-11-MeAIB is a metabolicallystable amino acid analogue specific for system A amino acid transport. We evaluated the biodistribution of C-11-MeAIB in rats and humans to estimate the usefulness of the tracer for in vivo human PET studies, for example, onregulation of system A amino acid transport and on tumour imaging. HealthySprague-Dawley rats (n=14) were killed 5, 20, 40 or 60 min after the injection of C-11-MeAIB, and the tissue samples were weighed and counted for C-11 radioactivity. Ten lymphoma patients with relatively limited tumour burden underwent whole-body (WB) PET imaging with C-11-MeAIB. In addition, threeother patients had dynamic PET scanning of the head and neck area, and thetracer uptake was quantitated by calculating the kinetic influx constants (K-i values) for the tracer. In animal studies, the highest activity was detected in the kidney, pancreas, adrenal gland and intestines. In humans, the highest activity was found in the salivary glands, and after that in the kidney and pancreas, similar to the results in animal studies. Rapid uptakewas also detected in the skeletal muscle. In the graphical analysis, linear plots were obtained, and the mean fractional tracer uptake values (K-i) of the parotid Cr glands (n=3) and cervical muscles (n=3) were 0.039 +/-0.008 min(-1) and 0.013 +/-0.006 min(-1), respectively. The Ki value of the tumour (n=1) was 0.064 min(-1). Higher uptake of C-11-MeAIB into the tumour tissue was encountered. These results encourage further C-11-MeAIB PET studies in humans on the physiology and pathology of system A amino acid transport and on tumour detection.

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Documento generato il 02/04/20 alle ore 12:40:35