Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Feeding suppression by fibroblast growth factor-1 is accompanied by selective induction of heat shock protein 27 in hypothalamic astrocytes
Autore:
Suzuki, S; Li, AJ; Ishisaki, A; Hou, XG; Hasegawa, M; Fukumura, M; Akaike, T; Imamura, T;
Indirizzi:
Natl Inst Adv Ind Sci & Technol, Gene Discovery Res Ctr, Tsukuba, Ibaraki 3058566, Japan Natl Inst Adv Ind Sci & Technol Tsukuba Ibaraki Japan 3058566 8566, Japan DNAVEC Res Inc, Tsukuba, Ibaraki 3050856, Japan DNAVEC Res Inc Tsukuba Ibaraki Japan 3050856 kuba, Ibaraki 3050856, Japan Tokyo Inst Technol, Dept Biomol Engn, Kanagawa 2268501, Japan Tokyo Inst Technol Kanagawa Japan 2268501 Engn, Kanagawa 2268501, Japan
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 12, volume: 13, anno: 2001,
pagine: 2299 - 2308
SICI:
0953-816X(200106)13:12<2299:FSBFGF>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CULTURED RAT ASTROCYTES; LONG-TERM POTENTIATION; HIGH-AFFINITY UPTAKE; ALPHA-B-CRYSTALLIN; SENDAI-VIRUS; FOOD-INTAKE; OBESE GENE; HSP27; EXPRESSION; PHOSPHORYLATION;
Keywords:
ciliary neurotrophic factor; gene profiling; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Imamura, T Natl Inst Adv Ind Sci & Technol, Gene Discovery Res Ctr, AIST Cent 6,1-1 Higashi, Tsukuba, Ibaraki 3058566, Japan Natl Inst Adv Ind Sci & Technol AIST Cent 6,1-1 Higashi Tsukuba Ibaraki Japan 3058566
Citazione:
S. Suzuki et al., "Feeding suppression by fibroblast growth factor-1 is accompanied by selective induction of heat shock protein 27 in hypothalamic astrocytes", EUR J NEURO, 13(12), 2001, pp. 2299-2308

Abstract

If has been suggested that fibroblast growth factor (FGF)-1 serves as a physiological satiety factor in the hypothalamus, although the molecular mechanism underlying such a function is poorly understood. To gain additional insight into this issue, we used a Sendai virus (SeV) gene expression systemin rats to explore genes differentially expressed subsequent to expressionof FGF-1. Using cDNA arrays, we determined that infusion of FGF-1/SeV intoone lateral ventricle induced selective expression of heat shock protein (HSP) 27 in the hypothalamus. Whereas FGF-1 expression was restricted to theependymal cell layer of the cerebral ventricles, HSP27 was more widely expressed in astrocytes residing in the surrounding periventricular region. Similarly, infusion of FGF-1 polypeptide into a lateral ventricle induced dose-dependent HSP27 expression in periventricular astrocytes surrounding the third ventricle, with maximum mRNA levels being attained 6 h after infusion. This induction of HSP27 was accompanied by a significant suppression of feeding behaviour. Interestingly, suppression of feeding caused by intracerebroventricular infusion of ciliary neurotrophic factor was also accompaniedby induction of HSP27 in periventricular astrocytes, but suppression of feeding caused by infusion of leptin was not. It therefore appears that suppression of feeding by FGF-1 is accompanied by selective induction of HSP27 expression in hypothalamic astrocytes surrounding the third ventricle, and that this response may be a key component of the mechanism by which appetiteis regulated by FGF-1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:14:54