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Titolo:
Long-lasting hippocampal potentiation and contextual memory consolidation
Autore:
Sacchetti, B; Lorenzini, CA; Baldi, E; Bucherelli, C; Roberto, M; Tassoni, G; Brunelli, M;
Indirizzi:
Univ Florence, Dept Physiol Sci, I-50134 Florence, Italy Univ Florence Florence Italy I-50134 hysiol Sci, I-50134 Florence, Italy Univ Pisa, Dept Physiol & Biochem G Moruzzi, I-56127 Pisa, Italy Univ Pisa Pisa Italy I-56127 ol & Biochem G Moruzzi, I-56127 Pisa, Italy
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 12, volume: 13, anno: 2001,
pagine: 2291 - 2298
SICI:
0953-816X(200106)13:12<2291:LHPACM>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIELD POTENTIALS; CONDITIONED-STIMULUS; INHIBITORY AVOIDANCE; RETROGRADE-AMNESIA; DORSAL HIPPOCAMPUS; SHORT-TERM; RATS; FEAR; PROTEIN; RETRIEVAL;
Keywords:
CA1 hippocampal slices; contextual fear conditioning memorization; exploration; input-output curves; nociceptive stimulation; paired-pulse facilitation curves;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Bucherelli, C Univ Florence, Dept Physiol Sci, Viale GB Morgagni 63, I-50134 Florence, Italy Univ Florence Viale GB Morgagni 63 Florence Italy I-50134 y
Citazione:
B. Sacchetti et al., "Long-lasting hippocampal potentiation and contextual memory consolidation", EUR J NEURO, 13(12), 2001, pp. 2291-2298

Abstract

In order to ascertain whether there are hippocampal electrophysiological modifications specifically related to memory, exploratory activity and emotional stress, extracellular electrical activity was recorded in hippocampal slices prepared from the brains of male adult rats. Several groups of animals were employed: (i) rats which had freely explored the experimental apparatus (8 min exposure); (ii) rats which had been subjected, in the same apparatus, to a fear conditioning paradigm training entailing the administration of aversive electrical footshocks (8 min exposure); (iii) rats to which the same number of aversive shocks had been administered in the same apparatus, but temporally compressed so as to make difficult the association between painful stimuli and the apparatus (30 s exposure); (iv) naive rats neverplaced in the apparatus. Half of the rats from each treatment group were used for retrieval testing and the other half for hippocampal excitability testing. The conditioned freezing response was exhibited for no less than 4 weeks. Hippocampal excitability was measured by means of input-output curves (IOC) and paired-pulse facilitation curves (PPF). Retrieval testing or brain slices preparation were performed at increasing delays after the training sessions: immediately afterwards or after 1, 7 or 28 days. Only the ratssubjected to the fear conditioning training exhibited freezing when placedagain in the apparatus (retrieval testing). It was found that IOCs, with respect to naive rats, increased in the conditioned animals up to the 7-day delay. In free exploration animals the IOCs increased only immediately after the training session. In all other rats no modification of the curves wasobserved. IOC increases do not appear to imply presynaptic transmitter release modifications, because they were not accompanied by PPF modifications. In conclusion, a clear-cut correlation was found between the increase in excitability of the Schaffer collateral-CA1 dendrite synapses and freezing response consolidation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 00:46:29