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Titolo:
Phase-coupled oscillator models can predict hippocampal inhibitory synaptic connections
Autore:
Skinner, FK; Wu, C; Zhang, L;
Indirizzi:
Univ Hlth Network, Toronto Western Res Inst, Toronto, ON, Canada Univ HlthNetwork Toronto ON Canada estern Res Inst, Toronto, ON, Canada Univ Toronto, Dept Med Neurol, Toronto, ON, Canada Univ Toronto Toronto ON Canada nto, Dept Med Neurol, Toronto, ON, Canada Univ Toronto, Dept Physiol, Toronto, ON, Canada Univ Toronto Toronto ON Canada oronto, Dept Physiol, Toronto, ON, Canada Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON, Canada Univ TorontoToronto ON Canada Biomat & Biomed Engn, Toronto, ON, Canada
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 12, volume: 13, anno: 2001,
pagine: 2183 - 2194
SICI:
0953-816X(200106)13:12<2183:POMCPH>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO; INTERSEGMENTAL COORDINATION; PROPAGATING WAVES; SYNCHRONIZED OSCILLATIONS; INTERNEURONAL NETWORKS; CORTICAL OSCILLATORS; SPREADING DEPRESSION; TERRESTRIAL MOLLUSK; PATTERN GENERATOR; PYRAMIDAL NEURON;
Keywords:
delta rhythm; interneurons; mathematical model; mouse; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Skinner, FK Univ Hlth Network, Toronto Western Res Inst, 399 Bathurst St,MP12-303, Toronto, ON, Canada Univ Hlth Network 399 Bathurst St,MP12-303 Toronto ON Canada
Citazione:
F.K. Skinner et al., "Phase-coupled oscillator models can predict hippocampal inhibitory synaptic connections", EUR J NEURO, 13(12), 2001, pp. 2183-2194

Abstract

What factors are responsible for propagating electrical activity in the hippocampus? Using an intact, isolated hippocampus preparation, it is possible to observe spontaneous delta (less than or equal to 4 Hz) waves of rhythmic field potentials. These rhythmic potentials are inhibitory in nature, mediated by GABAergic inhibitory potentials originating from a population of principal neurons. They start in the ventro-temporal region and move longitudinally towards the dorso-septal region with a phase lag of approximate to10% between the extracellular recordings. We use the mathematical framework of phase-coupled oscillators (PCO) to gain some insight into the underlying network system. A chain of 15 nearest-neighbour bidirectionally coupled PCOs is used where each oscillator refers to a segment of the CA1 region ofthe hippocampus that can generate these slow field potentials. We find that ventro-dorsal delta waves exist if there is a dominance in coupling strength in one direction. Without a one-way coupling dominance, ventro-dorsal waves can still exist, but then the coupling strengths need to be much larger. The relationship between entrained and intrinsic frequencies and the variation of propagation speeds along the longitudinal axis can be used to determine which case applies. Currently available experimental data supports one of the cases, predicting that there is a stronger ventral to dorsal inhibitory effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:47:47