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Titolo:
Left ventricular contractile performance in the early stage of hypertension in humans
Autore:
Palatini, P; Frigo, G; Visentin, P; Mario, L; Mormino, P; Pessina, AC;
Indirizzi:
Univ Padua, Clin Med 4, Dept Clin & Expt Med, I-35126 Padua, Italy Univ Padua Padua Italy I-35126 ept Clin & Expt Med, I-35126 Padua, Italy
Titolo Testata:
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1-2, volume: 85, anno: 2001,
pagine: 118 - 124
SICI:
1439-6319(200107)85:1-2<118:LVCPIT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
EJECTION FRACTION RESPONSE; END-SYSTOLIC STRESS; SYSTEMIC HYPERTENSION; MILD HYPERTENSION; HEALTHY-SUBJECTS; BLOOD-PRESSURE; EXERCISE; HYPERTROPHY; DYSFUNCTION; MECHANICS;
Keywords:
exercise; left ventricular function; echocardiography; hypertension;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Palatini, P Univ Padua, Clin Med 4, Dept Clin & Expt Med, Via Giustiniani 2, I-35126 Padua, Italy Univ Padua Via Giustiniani 2 Padua Italy I-35126 Padua, Italy
Citazione:
P. Palatini et al., "Left ventricular contractile performance in the early stage of hypertension in humans", EUR J A PHY, 85(1-2), 2001, pp. 118-124

Abstract

The aim of the present study was to assess how cardiac structural changes contribute to increasing left ventricular pump function during exercise in subjects with mild hypertension. In 23 young male subjects with mild hypertension and 12 male normotensive control subjects. left ventricular functionwas measured echocardiographically using the fractional shortening meridional stress relationship at rest and during longlasting exercise at the anaerobic threshold. Mean exercise duration and intensity were 61 (SEM 1.7) minand 71.3 (SEM 2.5)% (V)over dotO(2max) (maximal oxygen uptake), respectively, in the hypertensive subjects, and 63 (SEM 1.5) min and 75.7 (SEM 2.2)% (V)over dotO(2max), respectively, in the normotensive subjects (all differences = n.s.). Left ventricular fractional shortening was measured both at the endocardium and at the midwall. In the hypertensive subjects the endocardial fractional shortening, predicted on the basis of the shortening/stressrelationship in the normotensive controls, overestimated midwall fractional shortening throughout rest (P = 0.04) and exercise (P = 0.004). To study how an increase in left ventricular wall thickness contributed to increasing ejection performance during exercise, the hypertensive subjects were divided according to whether their relative wall thickness was less than 0.35 or equal to or greater than 0.35. Subjects with relative wall thicknesses equal to or greater than 0.35 had a depressed myocardial contractility at rest (P = 0.0001). During exercise they increased their stroke volume and cardiac output adequately through an increase in ejection performance, while myocardial contractility remained subnormal (P < 0.0001). In conclusion, the present results indicated that in mildly hypertensive subjects an increasedleft ventricular wall thickness is crucial in preserving left ventricular pump function during exercise.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:07:11