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Titolo:
Hyperbaric O-2 reduces intestinal ischemia-reperfusion-induced TNF-alpha production and lung neutrophil sequestration
Autore:
Yang, ZJ; Bosco, G; Montante, A; Ou, XI; Camporesi, EM;
Indirizzi:
SUNY, New York Upstate Med Ctr, Dept Anesthesiol, Cardiopulm Res Lab, Syracuse, NY 13210 USA SUNY Syracuse NY USA 13210 ol, Cardiopulm Res Lab, Syracuse, NY 13210 USA Univ Chieti, Sch Med, Human Physiol Lab, Dept Biomed Sci, Chieti, Italy Univ Chieti Chieti Italy an Physiol Lab, Dept Biomed Sci, Chieti, Italy SUNY, Upstate Med Univ, Univ Hosp, Dept Pathol, Syracuse, NY 13210 USA SUNY Syracuse NY USA 13210 Univ Hosp, Dept Pathol, Syracuse, NY 13210 USA
Titolo Testata:
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1-2, volume: 85, anno: 2001,
pagine: 96 - 103
SICI:
1439-6319(200107)85:1-2<96:HORIIT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; LOWER TORSO ISCHEMIA; GENE-EXPRESSION; OXYGEN THERAPY; PULMONARY SEQUESTRATION; LIPID-PEROXIDATION; INJURY; RAT; PERMEABILITY; ACTIVATION;
Keywords:
hyperbaric O-2; ischemia-reperfusion; TNF-alpha; lung injury; neutrophils;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Yang, ZJ SUNY, New York Upstate Med Ctr, Dept Anesthesiol, Cardiopulm Res Lab, Syracuse, NY 13210 USA SUNY Syracuse NY USA 13210 opulm Res Lab, Syracuse, NY 13210 USA
Citazione:
Z.J. Yang et al., "Hyperbaric O-2 reduces intestinal ischemia-reperfusion-induced TNF-alpha production and lung neutrophil sequestration", EUR J A PHY, 85(1-2), 2001, pp. 96-103

Abstract

Treatment with hyperbaric O-2 (HBO) ameliorates ischemia-reperfusion (I/R)injury. Since tumor necrosis factor-alpha (TNF-alpha) plays an important role in I/R injury, we hypothesized that the effect of HBO in I/R injury maybe due to its ability to inhibit TNF-alpha production. In this study, one group of rats received HBO during 60 min of ischemia (HBO group, n=9), while control rats endured the same procedure but did not receive HBO (non-HBO,n=9). A group of sham-operated control rats (SHAM, n=6) underwent laparotomy without occlusion of the artery and HBO treatment. Intestinal I/R led toan increase in serum TNF-a concentration to [mean (SEM)] 165 (32) pg/ml (P<0.01 vs SHAM rats). HBO attenuated this increase [34 (9) pg/ml; P<0.05 vs non-HBO group]. Intestinal I/R also resulted in a marked increase in lung myeloperoxidase content [0.62 (0.04) U/g vs 0.17 (0.02) U/g of SHAM rats, P<0.01]. HBO suppressed this increase [0.40 (0.04) U/g, P<0.05 vs non-HBO rats]. HBO ameliorated the injury to the intestine and lung. The number of neutrophils sequestered in the lung was reduced in HBO rats compared to non-HBO rats [6.4 (0.9) neutrophils/per oil field and 10.9 (2) neutrophils/per oil field, respectively; P<0.05]. These findings demonstrate that HBO inhibits TNF-<alpha> production during intestinal I/R, and this reduced TNF-a production may be attributed to the beneficial effects of HBO.

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Documento generato il 25/01/20 alle ore 06:54:40