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Titolo:
Impaired pressor response after spaceflight and bed rest: evidence for cardiovascular dysfunction
Autore:
Spaak, J; Sundblad, P; Linnarsson, D;
Indirizzi:
Karolinska Inst, Dept Physiol & Pharmacol, Sect Environm Physiol, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 siol, S-17177 Stockholm, Sweden
Titolo Testata:
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1-2, volume: 85, anno: 2001,
pagine: 49 - 55
SICI:
1439-6319(200107)85:1-2<49:IPRASA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
STATIC EXERCISE; ORTHOSTATIC INTOLERANCE; VENOUS-PRESSURE; HUMANS; MUSCLE; WEIGHTLESSNESS; MICROGRAVITY; CONTRACTION; MECHANISMS; VOLUME;
Keywords:
weightlessness; isometric exercise; blood pressure; muscle ischemia; muscle metaboreflex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Spaak, J Karolinska Inst, Dept Physiol & Pharmacol, Sect Environm Physiol,S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 7177 Stockholm, Sweden
Citazione:
J. Spaak et al., "Impaired pressor response after spaceflight and bed rest: evidence for cardiovascular dysfunction", EUR J A PHY, 85(1-2), 2001, pp. 49-55

Abstract

We hypothesized that impaired cardiovascular responses to isometric muscleaction contribute to the cardiovascular deconditioning that occurs after space flight (SF) and head-down-tilt bed rest (HDT). Six subjects were studied before, during and after 120 days of -6 degrees HDT, and four subjects were studied before, during (two subjects) and after 179-389 days of SF. Subjects performed a sustained handgrip (SHG) at a force equivalent to 30% of maximum contraction force for 2 min, and heart-rate (HR) and pressor (mean arterial pressure, Delta MAP) responses were recorded. At the same relativeforce, both Delta HR and Delta MAP were significantly reduced during the first days after HDT (-54%, P<0.05 and -43%, P<0.05). In two subjects studied within 24 h after their return from SF, Delta MAP was practically absent (-79%, P<0.05) whereas in four subjects studied 1-4 days after return from SF, <Delta>MAP was reduced by 35% (P<0.05). <Delta>HR was not significantlychanged. Our finding of attenuated pressor responses to SHG after HDT and SF supports the notion of impairments at both the neurocirculatory control and effector organ levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:51:32