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Titolo:
Atheromatous plaque formation and thrombogenesis: formation, risk factors and therapeutic approaches
Autore:
Badimon, L; Vilahur, G; Sanchez, S; Duran, X;
Indirizzi:
Univ Autonoma Barcelona, Hosp Santa Creu & San Pau, CSIC, Barcelona 08034,Spain Univ Autonoma Barcelona Barcelona Spain 08034 SIC, Barcelona 08034,Spain Inst Invest Biomed Barcelona, Cardiovasc Res Ctr, Barcelona 08034, Spain Inst Invest Biomed Barcelona Barcelona Spain 08034 arcelona 08034, Spain
Titolo Testata:
EUROPEAN HEART JOURNAL SUPPLEMENTS
fascicolo: I, volume: 3, anno: 2001,
pagine: I16 - I22
SICI:
1520-765X(200108)3:I<I16:APFATF>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; ACUTE MYOCARDIAL-INFARCTION; HUMAN ATHEROSCLEROTIC PLAQUES; UNSTABLE ANGINA-PECTORIS; TISSUE FACTOR; PLATELET DEPOSITION; CARDIOVASCULAR-DISEASE; VESSEL WALL; ANGIOGRAPHIC ASSESSMENT; PLASMINOGEN-ACTIVATOR;
Keywords:
atherogenesis; lipids; platelets; thrombosis; triflusal;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
84
Recensione:
Indirizzi per estratti:
Indirizzo: Badimon, L CSIC, Ctr Invest & Desarrollo, Jordi Girona 18-26, ES-08034 Barcelona, Spain CSIC Jordi Girona 18-26 Barcelona Spain ES-08034 celona, Spain
Citazione:
L. Badimon et al., "Atheromatous plaque formation and thrombogenesis: formation, risk factors and therapeutic approaches", EUR H J SUP, 3(I), 2001, pp. I16-I22

Abstract

Angiographic and ultrasound analyses of the coronary arteries have confirmed the importance of acute thrombosis as the primary cause of myocardial infarction and acute coronary syndromes. Intravenous treatments aimed at recanalizing the obstructed arteries can help achieve acute reperfusion of the organ, but often a thrombus-triggering plaque remains active for some time. It is not yet known how long a plaque remains active, but it has been shown that systemic markers of coagulation remain elevated as long as 6 months after the event. The presence of a residual mural thrombus overlying an active plaque predisposes to recurrent thrombotic vessel occlusion. A fragmented thrombus appears to be one of the most powerful thrombogenic substrates,and residual thrombus may predispose to recurrent thrombosis. Non-acute, chronic antithrombotic treatments and pharmacological interventions should aim to block thrombosis and preserve vascular prostacyclin formation. Experimental work has shogun that both aspirin and triflusal inhibit the growth of a thrombus on a fresh mural thrombus to the same extent, but triflusal was found to preserve cyclooxygenase-2 activity in the vessel wall. Research to uncover the mechanism of action of triflusal at the vascular level is inprogress. (C) 2001 The European Society of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:47:49