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Titolo:
Bisoprolol reduces cardiac death and myocardial infarction in high-risk patients as long as 2 years after successful major vascular surgery
Autore:
Poldermans, D; Boersma, E; Bax, JJ; Thomson, IR; Paelinck, B; van de Ven, LLM; Scheffer, MG; Trocino, G; Vigna, C; Baars, HF; van Urk, H; Roelandt, JRTC;
Indirizzi:
Erasmus Med Ctr, Rotterdam, Netherlands Erasmus Med Ctr Rotterdam Netherlands s Med Ctr, Rotterdam, Netherlands Univ Manitoba, Winnipeg, MB, Canada Univ Manitoba Winnipeg MB CanadaUniv Manitoba, Winnipeg, MB, Canada Univ Antwerp Hosp, Antwerp, Belgium Univ Antwerp Hosp Antwerp BelgiumUniv Antwerp Hosp, Antwerp, Belgium St Clara Hosp, Rotterdam, Netherlands St Clara Hosp Rotterdam Netherlands Clara Hosp, Rotterdam, Netherlands Twee Steden Ziekenhuis, Tilburg, Netherlands Twee Steden Ziekenhuis Tilburg Netherlands enhuis, Tilburg, Netherlands San Gerardo Hosp, Monza, Italy San Gerardo Hosp Monza ItalySan Gerardo Hosp, Monza, Italy Inst Ricovero & Cura Carattere Sci Hosp, San Giovanni Rotondo, Italy Inst Ricovero & Cura Carattere Sci Hosp San Giovanni Rotondo Italy taly
Titolo Testata:
EUROPEAN HEART JOURNAL
fascicolo: 15, volume: 22, anno: 2001,
pagine: 1353 - 1358
SICI:
0195-668X(200108)22:15<1353:BRCDAM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MORTALITY; MORBIDITY;
Keywords:
major vascular surgery; long-term follow-up; high-risk patients; beta-blockers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Poldermans, D Erasmus Univ, Thoraxctr, Room H921, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Room H921 Rotterdam Netherlands NL-3000 DR nds
Citazione:
D. Poldermans et al., "Bisoprolol reduces cardiac death and myocardial infarction in high-risk patients as long as 2 years after successful major vascular surgery", EUR HEART J, 22(15), 2001, pp. 1353-1358

Abstract

Aim To assess the long-term cardioprotective effect of bisoprolol in a randomized high-risk population after successful major vascular surgery. High-risk patients were defined by the presence of one or more cardiac risk factor(s) and a dobutamine echocardiography test positive for ischaemia. Methods 1351 patients were screened prior to surgery, 846 patients had oneor more risk factor(s), and 173 of these patients also had ischaemia during dobutamine echocardiography. One hundred and twelve patients could be randomized for additional bisoprolol therapy or standard care. Eleven patientsdied in the peri-operative period (up to 1 month after surgery). Randomized patients continued bisoprolol or standard care after surgery. During follow-up of 101 survivors (median 22 months, range 11-30) cardiac death or myocardial infarction was noted. No patient was lost during follow-up. Results The incidence of cardiac events during follow-up in the bisoprololgroup was 12% vs 32% in the standard care group (P=0.025). Cardiac death occurred in 15 patients, nine patients in the standard care and in six in the bisoprolol group; myocardial infarction occurred in six patients, five inthe standard care and one in the bisoprolol group. The odds ratio for cardiac death or myocardial infarction after surgery in high-risk patients withadditional bisoprolol therapy was 0.30 (0.11-0.83). Conclusions Bisoprolol significantly reduced long-term cardiac death and myocardial infarction in high-risk patients after successful major cardiac vascular surgery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 22:17:32