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Titolo:
Assessment of sublethal endpoints for toxicity testing with the nematode Caenorhabditis elegans
Autore:
Anderson, GL; Boyd, WA; Williams, PL;
Indirizzi:
Univ Georgia, Dept Environm Hlth Sci, Athens, GA 30602 USA Univ Georgia Athens GA USA 30602 Environm Hlth Sci, Athens, GA 30602 USA
Titolo Testata:
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
fascicolo: 4, volume: 20, anno: 2001,
pagine: 833 - 838
SICI:
0730-7268(200104)20:4<833:AOSEFT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ION CHARACTERISTICS; STRESS-RESPONSE; END-POINTS; SOIL; REPRODUCTION; SEDIMENTS; CADMIUM; STRAINS; HEAT; LC50;
Keywords:
nematodes; toxicity; sublethal endpoints; Caenorhabditis elegans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Williams, PL Univ Georgia, Dept Environm Hlth Sci, Athens, GA 30602 USA Univ Georgia Athens GA USA 30602 h Sci, Athens, GA 30602 USA
Citazione:
G.L. Anderson et al., "Assessment of sublethal endpoints for toxicity testing with the nematode Caenorhabditis elegans", ENV TOX CH, 20(4), 2001, pp. 833-838

Abstract

Toxicity tests in invertebrates often use sublethal endpoints, which may exhibit different sensitivity for various toxicants. Our objective was to characterize the sensitivity of movement, feeding, growth, and reproduction as endpoints for heavy metal toxicity testing with Caenorhabditis elegans. Growth and feeding were assessed in the same nematode samples used to assessmovement and reproduction. Median effective concentrations (EC50s) for 24-h exposures to Pb, Cu, and Cd were determined for movement, feeding, and growth and a 72-h EC50 was derived for reproduction. The order of toxicity was Cu > Pb > Cd for each endpoint, including lethality and movement. There were no differences in sensitivity among endpoints for any metal. When exposed for 4 h at (sublethal) concentrations that were 14 times the 24-h EC50 value, Pb and Cu reduced feeding to the same extent while movement was reduced significantly more by Pb than by Cu. Thus, a difference in sensitivity of endpoints was apparent at 4 h, which was not evident at 24 h. These observations suggest potentially different mechanisms of toxicity for 24- and 4-h tests.

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Documento generato il 06/04/20 alle ore 01:34:46