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Titolo:
Effects of nonylphenol, bisphenol A, and their mixture on the viviparous swordtail fish (Xiphophorus helleri)
Autore:
Kwak, HI; Bae, MO; Lee, MH; Lee, YS; Lee, BJ; Kang, KS; Chae, CH; Sung, HJ; Shin, JS; Kim, JH; Mar, WC; Sheen, YY; Cho, MH;
Indirizzi:
Seoul Natl Univ, Toxicol Lab, Suwon 441744, South Korea Seoul Natl Univ Suwon South Korea 441744 Lab, Suwon 441744, South Korea Seoul Natl Univ, Sch Agr Biotechnol, Suwon 441744, South Korea Seoul Natl Univ Suwon South Korea 441744 hnol, Suwon 441744, South Korea Seoul Natl Univ, Sch Biochem, Suwon 441744, South Korea Seoul Natl Univ Suwon South Korea 441744 chem, Suwon 441744, South Korea Seoul Natl Univ, Sch Publ Hlth, Suwon 441744, South Korea Seoul Natl UnivSuwon South Korea 441744 Hlth, Suwon 441744, South Korea Seoul Natl Univ, Sch Pathol, Coll Vet Med, Suwon 441744, South Korea SeoulNatl Univ Suwon South Korea 441744 Med, Suwon 441744, South Korea NIAST, RDA, Suwon 441744, South Korea NIAST Suwon South Korea 441744NIAST, RDA, Suwon 441744, South Korea Seoul Natl Univ, Nat Prod Res Inst, Seoul 110799, South Korea Seoul Natl Univ Seoul South Korea 110799 Inst, Seoul 110799, South Korea Ewha Womans Univ, Coll Pharm, Seoul 120750, South Korea Ewha Womans Univ Seoul South Korea 120750 arm, Seoul 120750, South Korea
Titolo Testata:
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
fascicolo: 4, volume: 20, anno: 2001,
pagine: 787 - 795
SICI:
0730-7268(200104)20:4<787:EONBAA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MINNOWS PIMEPHALES-PROMELAS; RAINBOW-TROUT; ESTROGENIC ACTIVITY; ALKYLPHENOLIC CHEMICALS; IN-VIVO; VITELLOGENIN; RAT; 4-NONYLPHENOL; HEPATOCYTES; DISRUPTION;
Keywords:
swordtail; endocrine disruptor; vitellogenesis; nonylphenol; bisphenol A;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Cho, MH Seoul Natl Univ, Toxicol Lab, Suwon 441744, South Korea Seoul NatlUniv Suwon South Korea 441744 won 441744, South Korea
Citazione:
H.I. Kwak et al., "Effects of nonylphenol, bisphenol A, and their mixture on the viviparous swordtail fish (Xiphophorus helleri)", ENV TOX CH, 20(4), 2001, pp. 787-795

Abstract

A number of fish species have been used for studies on endocrine disrupting chemicals (EDCs). However, despite the widespread use of oviparous fish, relatively little attention has been given to viviparous species. This study investigated the effects of EDCs in a viviparous fish and examined the possible usefulness of the fish as an alternative model for the studies on EDCs. Swordtails (Xiphophorus helleri) were exposed to nonylphenol (NP), bisphenol A (BPA), and their mixture. Both short-term (3-d) and relatively long-term (60-d) exposures were carried out using adult male and 30-d-old juvenile fish, respectively. Following the short-term exposure, both NP and BPA caused vitellogenin mRNA expression. Flow cytometric analysis and terminal deoxynucleotidyl transferase assay on the testes of treated fish indicated reproductive damage. Histopathological analysis found degenerative and necrotic cells in seminiferous tubules following the exposure to 100 ppb NP. The testes with lesions were also associated with highly suppressed spermatogenesis. Following the long-term exposure, both NP and BPA exposures significantly affected the growth of swordtails. In all cases, the results showed that the mixture was always more potent than a single chemical and that swordtail fish can be a useful model for the study of endocrine disruptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:31:21