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Titolo:
Effects of the synthetic estrogen 17 alpha-ethinylestradiol on the life-cycle of the fathead minnow (Pimephales promelas)
Autore:
Lange, R; Hutchinson, TH; Croudace, CP; Siegmund, F;
Indirizzi:
Schering AG, Res Labs, Expt Toxikol, D-13342 Berlin, Germany Schering AG Berlin Germany D-13342 Expt Toxikol, D-13342 Berlin, Germany AstraZeneca, Brixham Environm Lab, Brixham TQ5 8BA, Devon, England AstraZeneca Brixham Devon England TQ5 8BA Brixham TQ5 8BA, Devon, England Brunel Univ, Dept Biol & Biochem, Uxbridge UB8 3PH, Middx, England Brunel Univ Uxbridge Middx England UB8 3PH bridge UB8 3PH, Middx, England
Titolo Testata:
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
fascicolo: 6, volume: 20, anno: 2001,
pagine: 1216 - 1227
SICI:
0730-7268(200106)20:6<1216:EOTSE1>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAINBOW-TROUT; ENDOCRINE DISRUPTORS; AQUATIC ENVIRONMENT; ONCORHYNCHUS-MYKISS; STW EFFLUENT; CHEMICALS; VITELLOGENIN; FISH; IDENTIFICATION; ESTRADIOL;
Keywords:
ethinylestradiol; endocrine disruptor; estrogen; life-cycle; fish;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Lange, R Schering AG, Res Labs, Expt Toxikol, D-13342 Berlin, Germany Schering AG Berlin Germany D-13342 kol, D-13342 Berlin, Germany
Citazione:
R. Lange et al., "Effects of the synthetic estrogen 17 alpha-ethinylestradiol on the life-cycle of the fathead minnow (Pimephales promelas)", ENV TOX CH, 20(6), 2001, pp. 1216-1227

Abstract

A fish full life-cycle (FFLC) study was conducted for 17 alpha -ethinylestradiol (EE2) using the fathead minnow, Pimephales promelas. Newly fertilized embryos (< 24 h old) were exposed to five concentrations of EE2 (0.2, 1.0, 4.0, 16, and 64 ng/L nominal) in continuous flow-through conditions for 305 d at 25 :+/- 1 degreesC. Exposure concentrations were verified by C-14-EE2 radiochemistry, supported by radioimmunoassay, and mean measured values were greater than or equal to 70% of nominal. For the F-0 adult phase until301 d posthatch, the no-observed-effect concentrations (NOECs) for growth,survival, and reproduction (as egg production) were all greater than or equal to1.0 ng/L. The NOEC values for F-1 embryo hatching success and larval survival (at 28 d posthatch) were both greater than or equal to 1.0 ng/L. While statistically detectable changes in F-1 growth were evident at 0.2 ng/L, these were not considered to be biologically significant when compared with historical control data. Male fish exposed to EE2 at 4.0 ng/L failed todevelop normal secondary sexual characteristics; on the other hand, assumed females exposed to this level of EE2 were able to breed when paired with males that had not been exposed to EE2. Histology of F-0 control, 0.2-, and1-ng/L exposed fish at 56 d posthatch indicated an approximate female-to-male (F:M) sex ratio of 50:50 (with no ovatestes observed in the control), while fish exposed to EE, at 4.0 ng/L for 56 d posthatch had a F: M sex ratio of 84:5 (with ovatestes in 11 % of fish). After 172 d posthatch, no testicular tissue was observed in any fish exposed to EE2 at 4.0 ng/L. At the same time point, plasma vitellogenin levels were significantly higher in fishexposed to EE2 at 16 ng/ L. A lack of sexual differentiation occurred in males at concentrations greater than or equal to4.0 ng/L. Taking into account these data, the overall noobserved-adverse-effect concentration was considered to be 1.0 ng/L.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 19:54:46