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Titolo:
Determination of sialic acids in the serum of cancer patients by capillaryelectrophoresis
Autore:
Dong, XL; Xu, X; Han, F; Ping, XY; Yuang, XL; Lin, BC;
Indirizzi:
Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China Chinese Acad Sci Dalian Peoples R China 116023 n 116023, Peoples R China Dalian Third Minicipal Hosp, Dalian, Peoples R China Dalian Third Minicipal Hosp Dalian Peoples R China ian, Peoples R China Dalian Obstet & Gynecol Hosp, Dalian, Peoples R China Dalian Obstet & Gynecol Hosp Dalian Peoples R China an, Peoples R China Dalian Med Univ, Dalian, Peoples R China Dalian Med Univ Dalian Peoples R China ed Univ, Dalian, Peoples R China
Titolo Testata:
ELECTROPHORESIS
fascicolo: 11, volume: 22, anno: 2001,
pagine: 2231 - 2235
SICI:
0173-0835(200107)22:11<2231:DOSAIT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; N-GLYCOLYLNEURAMINIC ACIDS; ACETYLNEURAMINIC ACID; ULTRAVIOLET DETECTION; GLYCOPROTEINS; DERIVATIZATION; ACETYL;
Keywords:
capillary electrophoresis; sialic acids; cancer patients;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Lin, BC Chinese Acad Sci, Dalian Inst Chem Phys, 457 Zhongshan Rd, Dalian 116023, Peoples R China Chinese Acad Sci 457 Zhongshan Rd Dalian Peoples RChina 116023 a
Citazione:
X.L. Dong et al., "Determination of sialic acids in the serum of cancer patients by capillaryelectrophoresis", ELECTROPHOR, 22(11), 2001, pp. 2231-2235

Abstract

A novel method for the determination of N-acetylneuraminic acid (NANA) andN-glycolylneuraminic acid (NGNA) was developed by using high-performance capillary electrophoresis (HPCE) with UV detection at 195 nm. NANA and NGNA were separated directly and analyzed without pre- or postcolumn derivation. The detection limit of NANA is 9.6 x 10(-6) mol L-1 and for mass 3.879 x 10(-14) mol (39 fmol). This method was applied for the determination of NANAin 30 normal human and 72 cancer patients. The results demonstrated that NANA in the sera of cancer patients increased significantly as compared withthe normal human (P < 0.001). The new method is simple and sensitive, and is suitable for basic research and clinical application to malignant tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 05:41:14