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Titolo:
Lipid-rich carcinoid tumor of the thymus gland: Diagnosis by fine-needle aspiration biopsy
Autore:
Smith, NL; Finley, JL;
Indirizzi:
E Carolina Univ, Brody Sch Med, Dept Pathol & Lab Med, Greenville, NC 27858 USA E Carolina Univ Greenville NC USA 27858 Lab Med, Greenville, NC 27858 USA
Titolo Testata:
DIAGNOSTIC CYTOPATHOLOGY
fascicolo: 2, volume: 25, anno: 2001,
pagine: 130 - 133
SICI:
8755-1039(200108)25:2<130:LCTOTT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIASTINAL ENDOCRINE NEOPLASM; NEUROENDOCRINE CARCINOMAS; VARIANT;
Keywords:
neuroendocrine neoplasm; thymus gland; mediastinum; lipid; needle aspiration biopsy; cytology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, NL E Carolina Univ, Brody Sch Med, Dept Pathol & Lab Med, 7S-10 Brody Bldg, Greenville, NC 27858 USA E Carolina Univ 7S-10 Brody Bldg Greenville NC USA 27858 858 USA
Citazione:
N.L. Smith e J.L. Finley, "Lipid-rich carcinoid tumor of the thymus gland: Diagnosis by fine-needle aspiration biopsy", DIAGN CYTOP, 25(2), 2001, pp. 130-133

Abstract

In this report we describe the cytologic features of an unusual thymic carcinoid tumor containing prominent cytoplasmic lipid vacuoles that was diagnosed by fine-needle aspiration biopsy. The tumor presented as a presternal subcutaneous mass in an 81-yr-old female. with a contiguous mediastinal mass on computed tomography. The cytomorphologic features included numerous discohesive cells with eccentric, round to oval nuclei, granular chromatin, and scant cytoplasm containing numerous intracytoplasmic, clear vacuoles. The neoplastic cells were reactive for neuroendocrine markers by immunocytochemistry and showed reactivity of the intracytoplasmic vacuoles with an oil red-O stain for neutral lipid. Ultrastructural examination confirmed the presence of intracytoplasmic lipid vacuoles and neurosecretory granules. Subsequent surgical excision confirmed the diagnosis. We believe this to be thefirst report describing these features in a primary th, vinic carcinoid tumor. The differential diagnosis of mediastinal tumors with clear-cell features and cytoplasmic vacuolization is also discussed. (C) 2001 Wiley-Liss. Inc.

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Documento generato il 04/04/20 alle ore 02:35:22