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Titolo:
Isolation and expression analysis of three zebrafish angiopoietin genes
Autore:
Pham, V; Roman, BL; Weinstein, BM;
Indirizzi:
NICHD, Mol Genet Lab, NIH, Bethesda, MD 20892 USA NICHD Bethesda MD USA 20892 D, Mol Genet Lab, NIH, Bethesda, MD 20892 USA
Titolo Testata:
DEVELOPMENTAL DYNAMICS
fascicolo: 4, volume: 221, anno: 2001,
pagine: 470 - 474
SICI:
1058-8388(200108)221:4<470:IAEAOT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR TYROSINE KINASES; IN-SITU HYBRIDIZATION; ENDOTHELIAL-CELLS; TIE2 RECEPTOR; ANGIOGENESIS; NOTOCHORD; SURVIVAL; LIGANDS; XENOPUS; ANGPT1;
Keywords:
angiopoietin-1; angiopoietin-2; angiopoietin-like-3; zebrafish; hypochord; vascular development;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Weinstein, BM NICHD, Mol Genet Lab, NIH, Bldg 6B,Room 309,6 Ctr Dr, Bethesda, MD 20892 USA NICHD Bldg 6B,Room 309,6 Ctr Dr Bethesda MD USA 20892 92 USA
Citazione:
V. Pham et al., "Isolation and expression analysis of three zebrafish angiopoietin genes", DEV DYNAM, 221(4), 2001, pp. 470-474

Abstract

The Tie1 and Tie2 receptor tyrosine kinases and the Tie2 ligands, the angiopoietins, play critical roles in vertebrate vascular embryogenesis, helping to mediate the interaction between endothelial cells and the pericytes orvascular smooth muscle cells that envelop and support them. We have obtained full-length cDNA sequences for zebrafish orthologs of angiopoietin-1 (ang1), angiopoietin-2 (ang2), and angiopoietin-like-3 (angpt13). Ang1 is expressed in head ventral mesenchyme, in the ventromedial region of somites, inmesenchyme surrounding trunk axial vessels, and in the hypochord, a transient embryonic structure of endodermal origin that has been implicated in dorsal aorta assembly in both zebrafish and Xenopus. Ang2 is expressed in head and anterior trunk ventral mesenchyme and the-developing pronephric glomeruli. Angpt13 is expressed in the yolk syncytial layer. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 02:00:31