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Titolo:
Dorsal and Snail homologs in leech development
Autore:
Goldstein, B; Leviten, MW; Weisblat, DA;
Indirizzi:
Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 ll Biol, Berkeley, CA 94720 USA
Titolo Testata:
DEVELOPMENT GENES AND EVOLUTION
fascicolo: 7, volume: 211, anno: 2001,
pagine: 329 - 337
SICI:
0949-944X(200107)211:7<329:DASHIL>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MATERNAL MESSENGER-RNA; HELOBDELLA-TRISERIALIS; GLOSSIPHONIID LEECH; GENE; EXPRESSION; MESODERM; EMBRYO; NEUROGENESIS; EPITHELIUM; GASTROPODA;
Keywords:
leech; dorsal; snail; mesoderm; segmentation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Weisblat, DA Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA Univ Calif Berkeley 229 Stanley Hall Berkeley CA USA94720 SA
Citazione:
B. Goldstein et al., "Dorsal and Snail homologs in leech development", DEV GENES E, 211(7), 2001, pp. 329-337

Abstract

As part of an examination of how developmental mechanisms such as axis specification, cell fate specification, and segmentation have evolved, we havecloned homologs of the Drosophila melanogaster genes dorsal and snail fromthe glossiphoniid leech Helobdella robusta. Sequences from one dorsal-class gene (Hro-dl) and two snail-class genes (Hro-sna1 and Hro-sna2) were identified. Polyclonal antibodies were raised against the most conserved domains of HRO-DL and HRO-SNA1 Nuclear staining appeared for both proteins in mid-embryogenesis, in mesodermal and ectodermal precursors. During segmentation, segmentally iterated stripes of cells with strong HRO-DL staining appeared. The stripes of HRO-DL staining were first concentrated in the cytoplasmof cells, and later in the nuclei. Around this time, HRO-SNA levels also appeared in nuclei in segmentally iterated stripes. The localization of HRO-DL and HRO-SNA proteins raise the possibility that these genes are part of a conserved genetic pathway that, instead of specifying the dorsoventral axis and the mesoderm as in flies, might play a role in the diversification of cell types within segment primordia during leech development.

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Documento generato il 05/04/20 alle ore 03:35:29