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Titolo:
17-beta-estradiol suppresses IL-2 and IL-2 receptor
Autore:
McMurray, RW; Ndebele, K; Hardy, KJ; Jenkins, JK;
Indirizzi:
Univ Mississippi, Med Ctr, Div Rheumatol, Jackson, MS 39216 USA Univ Mississippi Jackson MS USA 39216 iv Rheumatol, Jackson, MS 39216 USA Univ Mississippi, Med Ctr, GV Sonny Montgomery VA Hosp, Rheumatol Sect, Jackson, MS 39216 USA Univ Mississippi Jackson MS USA 39216 eumatol Sect, Jackson, MS 39216 USA Univ Mississippi, Med Ctr, Dept Med, Div Rheumatol & Mol Immunol, Jackson,MS 39216 USA Univ Mississippi Jackson MS USA 39216 & Mol Immunol, Jackson,MS 39216 USA
Titolo Testata:
CYTOKINE
fascicolo: 6, volume: 14, anno: 2001,
pagine: 324 - 333
SICI:
1043-4666(20010621)14:6<324:1SIAIR>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; SYSTEMIC-LUPUS-ERYTHEMATOSUS; BLOOD T-CELLS; GENE-EXPRESSION; ESTROGEN-RECEPTOR; SEX-HORMONES; GLUCOCORTICOID RECEPTOR; INTERLEUKIN-2 GENE; SIGNAL-TRANSDUCTION; HUMAN-LYMPHOCYTES;
Keywords:
interleukin-2; estrogen; transcription; immunity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: McMurray, RW Univ Mississippi, Med Ctr, Div Rheumatol, L525 Clin Sci Bldg,2500 N State St, Jackson, MS 39216 USA Univ Mississippi L525 Clin Sci Bldg,2500 N State St Jackson MS USA 39216
Citazione:
R.W. McMurray et al., "17-beta-estradiol suppresses IL-2 and IL-2 receptor", CYTOKINE, 14(6), 2001, pp. 324-333

Abstract

Interleukin-2 (IL-2) plays an important role in adaptive immune responses. These responses differ between females and males and may be due to the sexsteroid estrogen. In this investigation we show that estrogen suppresses IL-2 production from activated peripheral blood T cells and CD4+ T cell lines at the transcriptional level. Suppression of IL-2 occurred at short term,high 17-beta -estradiol concentrations as well as longer term lower 17-beta -estradiol concentrations. In CD4+ Jurkat T cells, suppression of IL-2 was associated with decreased nuclear binding of two important IL-2 promoter transcription factors: NF kappaB and AP-1. The decreased nuclear binding ofNF kappaB occurred in the setting of estrogen-induced increases in I kappaB alpha protein levels, an important inhibitor of NF kappaB nuclear translocation. 17-beta -Estradiol was also shown to inhibit IL-2 receptor (IL-2R) expression in activated peripheral blood T cells. Estrogen-induced suppression of IL-2 and its receptor may have many ramifications for our understanding of immune and autoimmune sexual dichotomies, immune responses during pregnancy, and potential therapeutic intervention with hormone agonists and antagonists. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:03:31