Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Biology of the X chromosome
Autore:
Gartler, SM; Goldman, MA;
Indirizzi:
Univ Washington, Dept Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ton, Dept Med, Seattle, WA 98195 USA Univ Washington, Dept Genet, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 n, Dept Genet, Seattle, WA 98195 USA San Francisco State Univ, Dept Biol, San Francisco, CA 94132 USA San Francisco State Univ San Francisco CA USA 94132 ancisco, CA 94132 USA
Titolo Testata:
CURRENT OPINION IN PEDIATRICS
fascicolo: 4, volume: 13, anno: 2001,
pagine: 340 - 345
SICI:
1040-8703(200108)13:4<340:BOTXC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
STATIONARY NIGHT BLINDNESS; INACTIVATION CENTER; REPEAT HYPOTHESIS; HISTONE MACROH2A1; MOUSE EMBRYOS; RETT-SYNDROME; GENE; METHYLATION; MUTATIONS; INHERITANCE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Gartler, SM Univ Washington, Dept Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 d, Seattle, WA 98195 USA
Citazione:
S.M. Gartler e M.A. Goldman, "Biology of the X chromosome", CURR OP PED, 13(4), 2001, pp. 340-345

Abstract

The biology of the X chromosome is unique, as there are two Xs, in femalesand only a single X in mates, whereas the autosomes are present in duplicate in both sexes. The presence of only a single autosome, which can occur as a result of an error in meiotic segregation, is invariably an embryonic lethal event. Monosomy for the X chromosome is viable because of dosage compensation, a system found in all organisms with an X:Y form of sex determination, which brings about equality of expression of most X-linked genes in females and males. In mammals, the dosage compensation system involves silencing of most of the genes on one X chromosome; it is called X chromosome inactivation. In this review, we focus first on recent advances in our understanding of the molecular basis of the X inactivation mechanism. Then we consider an unusual feature of X inactivation, the mosaic nature of the femaleand subsequent exposure to somatic cell selection. (C) 2001 Lippincott Williams & Wilkins, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:21:12