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Titolo:
Influence of Dacron tissue thickness on the performance of the Pintucci biointegrable keratoprosthesis - An in vitro and in vivo study
Autore:
Pintucci, S; Perilli, R; Formisano, G; Caiazza, S;
Indirizzi:
Ist Super Sanita, Ultrastrutture Lab, I-00161 Rome, Italy Ist Super Sanita Rome Italy I-00161 rastrutture Lab, I-00161 Rome, Italy
Titolo Testata:
CORNEA
fascicolo: 6, volume: 20, anno: 2001,
pagine: 647 - 650
SICI:
0277-3740(200108)20:6<647:IODTTO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
STAPHYLOCOCCUS-EPIDERMIDIS;
Keywords:
Dacron; keratoprosthesis; light microscopy; scanning electron microscopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Caiazza, S Ist Super Sanita, Ultrastrutture Lab, Viale Regina Elena 299, I-00161 Rome, Italy Ist Super Sanita Viale Regina Elena 299 Rome Italy I-00161 aly
Citazione:
S. Pintucci et al., "Influence of Dacron tissue thickness on the performance of the Pintucci biointegrable keratoprosthesis - An in vitro and in vivo study", CORNEA, 20(6), 2001, pp. 647-650

Abstract

Purpose. In 1979 Pintucci developed a biointegrable keratoprosthesis with polymethylmethacrylate optical cylinder integrated with a Dacron tissue-colonizable supporting element to avoid the complications caused by the interaction between the haptic element and the eye. The purpose of this article is to compare the colonization of three Dacron fabrics (thicknesses of 0.25 min,. mm, and 1.4 mm) in vitro and in vivo to optimize the device performance. Methods. In vitro three different Dacron fabrics were cultured for 3 days with 3.5 x 10(5) human fetal lung fibroblasts and observed with a scanning electron microscope. In vivo three different Dacron fabrics were implanted on the sclera near the superior rectus insertion in the right eye of sixalbino rabbits and were observed after 4 days with light and scanning electron microscopy. Results. In the in vitro experiments, the cells were preserved and their structure was found to be normal. The 0.25-mm thick fabric was coated only on the surface, and the other fabrics were colonized in three dimensions. In the in vivo experiments, the 0.25-mm thick fabric appearedcoated only on its surface. The other fabrics were three-dimension ally colonized and the Dacron filaments appeared embedded in neovascularized connective tissue with minimal foreign body reaction. The 1.4-mm thick colonizedfabric showed a substantial loss of pliability. Conclusion. Given that the0.25-mm thick fabric was coated only by connective tissue, that the 0.6-mmand 1.4-mm thick fabrics were perfectly colonized, and that the 1.4-mm thick fabrics showed a substantial loss of pliability, the 0.6-mm thick fabrichaptic part of the Pintucci keratoprosthesis is preferred. For 19 years, the 0.6-mm Dacron fabric Pintucci keratoprosthesis was implanted in 159 eyeswith good results, overcoming the apparently inseparable difficulties represented by mechanical anchorage and biointegrability of a keratoprosthesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 04:09:44