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Titolo:
Chronic myelocytic leukemia in a juvenile rhesus macaque (Macaca mulatta)
Autore:
Krugner-Higby, LA; Gendron, A; Laughlin, NK; Luck, M; Scheffler, J; Phillips, B;
Indirizzi:
Univ Wisconsin, Res Anim Resource Ctr, Enzyme Inst 396, Madison, WI 53705 USA Univ Wisconsin Madison WI USA 53705 nzyme Inst 396, Madison, WI 53705 USA Univ Wisconsin, Harlow Ctr Biol Psychol, Madison, WI USA Univ Wisconsin Madison WI USA , Harlow Ctr Biol Psychol, Madison, WI USA Univ Wisconsin, Wisconsin Reg Primate Res Ctr, Madison, WI USA Univ Wisconsin Madison WI USA onsin Reg Primate Res Ctr, Madison, WI USA Univ Wisconsin, Sch Vet Med, Madison, WI 53706 USA Univ Wisconsin MadisonWI USA 53706 n, Sch Vet Med, Madison, WI 53706 USA
Titolo Testata:
CONTEMPORARY TOPICS IN LABORATORY ANIMAL SCIENCE
fascicolo: 4, volume: 40, anno: 2001,
pagine: 44 - 48
SICI:
1060-0558(200107)40:4<44:CMLIAJ>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; CHRONIC MYELOID-LEUKEMIA; EPSTEIN-BARR-VIRUS; LYMPHOPROLIFERATIVE DISEASE; MYELODYSPLASTIC SYNDROMES; PROGENITOR CELLS; SMELTER WORKERS; LEAD NITRATE; ERYTHROPOIETIN; EXPOSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Krugner-Higby, LA Univ Wisconsin, Res Anim Resource Ctr, Enzyme Inst 396, 1710 Univ Ave, Madison, WI 53705 USA Univ Wisconsin 1710 Univ Ave Madison WI USA 53705 05 USA
Citazione:
L.A. Krugner-Higby et al., "Chronic myelocytic leukemia in a juvenile rhesus macaque (Macaca mulatta)", CONT T LAB, 40(4), 2001, pp. 44-48

Abstract

Myeloid neoplasia has been studied extensively in human beings but has notbeen reported in macaques. A 2-year-old female rhesus macaque that was experimentally exposed to lead as a neonate, was noted to have immature circulating myelocytic cells, including 1% blasts, and normocytic normochromic anemia on a blood sample obtained for monthly health monitoring. The animal was treated with hydroxyurea, blood transfusion, and recombinant human erythropoietin to reduce the leukocytosis and correct the anemia. The disease had a relatively indolent course for 3 months, when it progressed to blast crisis. After the onset of blast crisis, the animal was euthanized because ofbleeding problems, anemia, and a progressive decline in her health. The animal was negative by serology, polymerase chain reaction (PCR) assays, and/or culture for simian retrovirus (SRV), simian T-lymphotropic virus type I (STLV-I), and simian immunodeficiency virus (SIV). PCR assay for the bcr-ABL chromosomal translocation using primers made for the human gene was negative. Serology for Epstein-Barr virus (EBV)-like viruses was positive for IgG directed against the viral nucleocapsid antigen, but epidemiologic factors make it unlikely that the leukemia was associated with EBV-induced viral transformation. Lead exposure has been associated with neoplasia in human beings, and the possible role of neonatal lead exposure in hematologic neoplasias deserves further scrutiny.

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Documento generato il 29/09/20 alle ore 10:32:51