Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Analgesic effects of peripherally administered opioids in clinical models of acute and chronic inflammation
Autore:
Dionne, RA; Lepinski, AM; Gordon, SM; Jaber, L; Brahim, JS; Hargreaves, KM;
Indirizzi:
Natl Inst Dent & Craniofacial Res, Pain & Neurosensory Mech Branch, NIH, Bethesda, MD 20892 USA Natl Inst Dent & Craniofacial Res Bethesda MD USA 20892 sda, MD 20892 USA Univ Minnesota, Sch Dent, Minneapolis, MN USA Univ Minnesota Minneapolis MN USA nnesota, Sch Dent, Minneapolis, MN USA
Titolo Testata:
CLINICAL PHARMACOLOGY & THERAPEUTICS
fascicolo: 1, volume: 70, anno: 2001,
pagine: 66 - 73
SICI:
0009-9236(200107)70:1<66:AEOPAO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTHROSCOPIC KNEE SURGERY; INTRAARTICULAR MORPHINE; INFLAMED TISSUE; PAIN CONTROL; BUPIVACAINE; HYPERALGESIA; INVOLVEMENT; RECEPTORS; ANALOG; NERVE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Dionne, RA Natl Inst Dent & Craniofacial Res, Pain & Neurosensory Mech Branch, NIH, Bldg 10,Room 1N-117, Bethesda, MD 20892 USA Natl Inst Dent & Craniofacial Res Bldg 10,Room 1N-117 Bethesda MD USA 20892
Citazione:
R.A. Dionne et al., "Analgesic effects of peripherally administered opioids in clinical models of acute and chronic inflammation", CLIN PHARM, 70(1), 2001, pp. 66-73

Abstract

A series of double-blind, placebo-controlled clinical trials demonstrated that low doses of morphine (0.4, 1.2, and 3.6 mg) administered into the intraligamentary space of a chronically inflamed hyperalgesic tooth produced adose-related naloxone-reversible analgesia. This analgesic effect is mediated by a local mechanism in the inflamed tissue, because subcutaneous administration of a 1.2 mg dose of morphine failed to elicit an analgesic response. In contrast, submucosal administration of 1.2 mg morphine or 50 mug fentanyl to the site of extraction of an impacted third molar after the onset of acute pain failed to elicit an analgesic response despite demonstration of a sensitive bioassay. These data indicate that peripheral opioid analgesia can be evoked in a model of chronic, but not acute, inflammatory pain, suggesting a temporal dependent mechanism needed for the expression of peripheral opiate analgesia during inflammation in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 12:50:47