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Titolo:
The prolonged cortical silent period in patients with Huntington's disease
Autore:
Modugno, N; Curra, A; Giovannelli, M; Priori, A; Squitieri, F; Ruggieri, S; Manfredi, M; Berardelli, A;
Indirizzi:
Univ Roma La Sapienza, Dipartimento Sci Neurol, I-00185 Rome, Italy Univ Roma La Sapienza Rome Italy I-00185 Sci Neurol, I-00185 Rome, Italy Osped Maggiore, IRCCS, Ist Neurol Mediterraneo Neuromed, Milan, Italy Osped Maggiore Milan Italy t Neurol Mediterraneo Neuromed, Milan, Italy Univ Milan, Osped Maggiore, IRCCS, Ist Clin Neurol, Milan, Italy Univ Milan Milan Italy d Maggiore, IRCCS, Ist Clin Neurol, Milan, Italy
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 8, volume: 112, anno: 2001,
pagine: 1470 - 1474
SICI:
1388-2457(200108)112:8<1470:TPCSPI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRANIAL MAGNETIC STIMULATION; BRAIN-STIMULATION; MOTOR CORTEX; MOVEMENT; BRADYKINESIA; INHIBITION; CHOREA; SINGLE;
Keywords:
Huntington's disease; chorea; silent period; transcranial magnetic stimulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Berardelli, A Univ Roma La Sapienza, Dipartimento Sci Neurol, Viale Univ 30, I-00185 Rome, Italy Univ Roma La Sapienza Viale Univ 30 Rome Italy I-00185 taly
Citazione:
N. Modugno et al., "The prolonged cortical silent period in patients with Huntington's disease", CLIN NEU, 112(8), 2001, pp. 1470-1474

Abstract

Objectives: In a group of patients with Huntington's disease and age-matched controls, we studied the cortical silent period (SP) elicited by single transcranial magnetic stimulation (TMS) pulses. Methods: We measured the area of the pre-stimulus electromyographic (EMG) activity, the area of the motor evoked potentials (MEPs) and the duration of the SP induced by stimuli delivered at an intensity of 150% of motor threshold with a round coil placed over the vertex. We determined the cortical SP by sampling only the 5 traces containing the shortest SPs and by collecting 10 consecutive unselected traces without selecting trials. Results: Patients and controls had normal EMG background areas, and MEP latencies and areas. Whereas data measured from selected trials gave a normalduration of the SP (patients, 154 +/- 58 ins, controls, 166 +/- 22 ms), data from unselected trials yielded a significantly longer SP duration in patients than in controls (356 +/- 251 vs. 159 +/- 44 ms) and also a lamer variance and range. Conclusions: We conclude that in Huntington's disease, an abnormal cortical SP is best sought by collecting unselected consecutive traces. We suggestthat the prolonged SP in HD originates from a dysfunction of the mechanisms controlling the restart of voluntary movement after TMS. (C) 2001 Elsevier Science Ireland Ltd. All ri-hts reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:01:38