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Titolo:
Amelioration of frozen gait by tandospirone, a serotonin 1A agonist, in a patient with pure akinesia developing resistance to L-threo-3,4-dihydroxyphenylserine
Autore:
Miyata, S; Hamamura, T; Yoshinaga, J; Nakamura, Y; Imamura, T; Hikiji, A; Kuroda, S;
Indirizzi:
Okayama Univ, Sch Med, Dept Neuropsychiat, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 Neuropsychiat, Okayama 7008558, Japan Hiroshima City Hosp, Dept Neurol, Okayama, Japan Hiroshima City Hosp Okayama Japan ity Hosp, Dept Neurol, Okayama, Japan
Titolo Testata:
CLINICAL NEUROPHARMACOLOGY
fascicolo: 4, volume: 24, anno: 2001,
pagine: 232 - 234
SICI:
0362-5664(200107/08)24:4<232:AOFGBT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; TARDIVE-DYSKINESIA; BUSPIRONE; RAT;
Keywords:
pure akinesia; frozen gait; L-threo-DOPS; tandospirone; noradrenaline-serotonin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Hamamura, T Okayama Univ, Sch Med, Dept Neuropsychiat, 2-5-1 Shikata Cho, Okayama 7008558, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan 7008558 8, Japan
Citazione:
S. Miyata et al., "Amelioration of frozen gait by tandospirone, a serotonin 1A agonist, in a patient with pure akinesia developing resistance to L-threo-3,4-dihydroxyphenylserine", CLIN NEUROP, 24(4), 2001, pp. 232-234

Abstract

A 71-year-old woman presented with severe akinesia, frozen gait, and compromised postural reflexes, without rigidity, tremor, or vertical gaze disturbance. With a working diagnosis of pure akinesia, we administered amantadine (150 mg/d) and L-threo-3,4-dihydroxyphenylserine (DOPS) (600 mg/d). Whichalleviated her symptoms. When frozen gait recurred 2 months later, we increased the dose of L-threo-DOPS to 900 mg/d and added levodopa (300 mg/d) combined With carbidopa, but this failed to improve the patient's symptoms. We then combined administration of tandospirone, a serotonin (5-HT) 1A agonist with L-threo-DOPS (600 mg/d), resulting in marked clinical improvement. Tandospirone is reported to activate noradrenergic neurons via the 5-HT 1A receptor, which could account for such striking improvement in a patient previously responsive to the noradrenergic precursor L-threo-DOPS given alone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 06:52:10