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Titolo:
Neurobiology and clinical pharmacology of obsessive-compulsive disorder
Autore:
Micallef, J; Blin, O;
Indirizzi:
Univ Mediterranee, Timone Unv Hosp, Ctr Pharmacol & Evaluat Therapeut, F-13385 Marseille 5, France Univ Mediterranee Marseille France 5 rapeut, F-13385 Marseille 5, France Univ Mediterranee, Timone Unv Hosp, Dept Clin Pharmacol, F-13385 Marseille, France Univ Mediterranee Marseille France F-13385 ol, F-13385 Marseille, France
Titolo Testata:
CLINICAL NEUROPHARMACOLOGY
fascicolo: 4, volume: 24, anno: 2001,
pagine: 191 - 207
SICI:
0362-5664(200107/08)24:4<191:NACPOO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOSE METABOLIC RATES; CORTICOTROPIN-RELEASING-FACTOR; SEROTONIN REUPTAKE INHIBITORS; SCHEDULE-INDUCED-POLYDIPSIA; CEREBRAL BLOOD-FLOW; QUALITY-OF-LIFE; DOUBLE-BLIND; BASAL GANGLIA; CLOMIPRAMINE TREATMENT; SPECTRUM DISORDERS;
Keywords:
obsessive-compulsive disorder; neurobiology; treatment; review;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
149
Recensione:
Indirizzi per estratti:
Indirizzo: Blin, O Univ Mediterranee, Timone Unv Hosp, Ctr Pharmacol & Evaluat Therapeut, F-13385 Marseille 5, France Univ Mediterranee Marseille France 5 F-13385 Marseille 5, France
Citazione:
J. Micallef e O. Blin, "Neurobiology and clinical pharmacology of obsessive-compulsive disorder", CLIN NEUROP, 24(4), 2001, pp. 191-207

Abstract

Obsessive-compulsive disorder (OCD) is a brain disorder with recognizable periods of onset, course, familial occurrence, epidemiology, phenomenology,and treatment response. Several manifestations of pathophysiology are beginning to be defined, although they may represent intermediate pathophysiology rather than primary etiology. Positron emission tomography studies have consistently identified hypermetabolism in the orbitofrontal cortex, caudate nucleus, and, sometimes, anterior cingulate cortex. Neuropsychologic testing frequently identifies abnormalities in visuospatial function. Abnormal levels of cerebrospinal fluid neurotransmitters and neuromodulators are identifiable in untreated patients with OCD and return toward normal levels after effective treatment. The most consistent pathophysiologic finding in OCD points toward an abnormality in serotonin neurotransmission. Therapeutic response to selective serotonin reuptake inhibitors and the absence of improvement with norepinephrine reuptake inhibitors and dopamine antagonists argue strongly for a role of serotonin in the pathophysiology and treatment of OCD. Despite this clear indication front treatment trials, probes and manipulations of the serotonin system and its specific receptors have not provided a useful understanding of specific abnormalities. Clomipramine or potent selective serotonin reuptake inhibitors are the pharmacotherapy of choice for OCD, With a more limited role reserved for monoamine oxidase inhibitors. If one selective serotonin reuptake inhibitor is ineffective, others may be beneficial, in addition to the different proserotonergic and nonserotonergic augmentation strategies that could be useful in treatment of resistant OCD patients. Nondrug therapies are also important in OCD: behavioral therapy is frequently helpful and neurosurgery is sometimes helpful when other treatments fail.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:52:12