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Titolo:
Hyperthyroidism is associated with lengthening of ventricular repolarization
Autore:
Colzani, RM; Emdin, M; Conforti, F; Passino, C; Scarlattini, M; Iervasi, G;
Indirizzi:
CNR, Inst Clin Physiol, Cardiovasc Neuroendocrine Unit, I-56126 Pisa, Italy CNR Pisa Italy I-56126 rdiovasc Neuroendocrine Unit, I-56126 Pisa, Italy
Titolo Testata:
CLINICAL ENDOCRINOLOGY
fascicolo: 1, volume: 55, anno: 2001,
pagine: 27 - 32
SICI:
0300-0664(200107)55:1<27:HIAWLO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
QT INTERVAL PROLONGATION; DIABETIC AUTONOMIC NEUROPATHY; SUDDEN CARDIAC DEATH; THYROID-HORMONE; MYOCARDIAL-INFARCTION; HEART; POTENTIALS; MORTALITY; FORMULAS; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Iervasi, G CNR, Inst Clin Physiol, Cardiovasc Neuroendocrine Unit, Via P Savi 8, I-56126 Pisa, Italy CNR Via P Savi 8 Pisa Italy I-56126 avi 8, I-56126 Pisa, Italy
Citazione:
R.M. Colzani et al., "Hyperthyroidism is associated with lengthening of ventricular repolarization", CLIN ENDOCR, 55(1), 2001, pp. 27-32

Abstract

OBJECTIVE Lengthened ventricular repolarization, as assessed by the QT interval on electrocardiogram (ECG), can predispose to an increased risk of cardiac dysrhythmias; no data are available on QT corrected for heart rate (QTc) in hyperthyroidism in vivo. DESIGN QT and RR intervals from 24 h ambulatory ECG Holter recording were measured in patients with hyperthyroidism and again following pharmacological achievement of stable euthyroidism for at least 2 months. PATIENTS We enrolled a total of 16 hyperthyroid patients with Graves' disease, six males and 10 females (mean age 47 +/- 4 years, mean +/- SEM); 13 healthy age- and sex-matched subjects were utilized as a control group. MEASUREMENTS The QT analysis was carried out by a computerized algorithm (QTc was corrected by the heart rate by Bazett's formula). Serum total T4, total T3, free T4, free T3 and TSH concentrations were measured by a fully automated immunoenzymometric assay; plasma norepinephrine by automatized high-pressure liquid chromatography, potassium and chloride by a potentiometric method, magnesium and calcium by a colourimetric method. RESULTS The 24-h average QTc in the hyperthyroid patients was significantly prolonged compared to controls (458 +/- 7 vs. 431 +/- 6 ms, P = 0.01) andit returned to normal after treatment of thyrotoxicosis (432 +/- 6 ms, P <0.05 vs. time H, NS vs. controls). QTc positively correlated with FT3 (r =0.63, P < 0.001) and with FT4 (r = 0.481, P < 0.02). Conversely, QTc did not correlate with plasma basal norepinephrine levels, nor with electrolytes. CONCLUSIONS Hyperthyroidism is associated with prolonged QTc that normalizes once the patient becomes euthyroid. The strong positive correlation between FT3 and QTc supports the hypothesis of an important role of thyroid hormone on modulation of QTc lengthening.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 18:58:34