Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Epitope spreading: protection from pathogens, but propagation of autoimmunity?
Autore:
Powell, AM; Black, MM;
Indirizzi:
St Thomas Hosp, St Johns Inst Dermatol, IMF Dept, London SE1 7EH, England St Thomas Hosp London England SE1 7EH IMF Dept, London SE1 7EH, England
Titolo Testata:
CLINICAL AND EXPERIMENTAL DERMATOLOGY
fascicolo: 5, volume: 26, anno: 2001,
pagine: 427 - 433
SICI:
0307-6938(200107)26:5<427:ESPFPB>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMIC-ACID DECARBOXYLASE; LICHEN-PLANUS-PEMPHIGOIDES; T-CELL TOLERANCE; DERMATITIS-HERPETIFORMIS; MULTIPLE-SCLEROSIS; SELF-RECOGNITION; IMMUNE-RESPONSE; MICE; ENCEPHALOMYELITIS; COEXISTENCE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Powell, AM St Thomas Hosp, St Johns Inst Dermatol, IMF Dept, Lambeth Palace Rd, London SE1 7EH, England St Thomas Hosp Lambeth Palace Rd London England SE1 7EH ngland
Citazione:
A.M. Powell e M.M. Black, "Epitope spreading: protection from pathogens, but propagation of autoimmunity?", CLIN EXP D, 26(5), 2001, pp. 427-433

Abstract

An epitope is an antigenic determinant, or a site on the surface of an antigenic molecule, to which a single antibody binds. Epitope spreading (ES) refers to the development of an immune response to epitopes distinct from, and noncross-reactive with, the disease-causing epitope. Diversification. orthe ability of the immune system to attack multiple targets on a pathogen has obvious advantages. Here we review some of the evidence regarding its role in autoimmunity, in humans and in animal disease models. We consider the implications of ES on the development of highly specific therapies for autoimmune disease. We stress that pathogenic ES probably occurs in the context of inherent abnormalities in control mechanisms for the prevention of autoimmunity or other genetic predisposing factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:12:56