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Titolo:
Novel drug-delivery stent - Intravascular ultrasound observations from thefirst human experience with the QP2-eluting polymer stent system
Autore:
Honda, Y; Grube, E; de la Fuente, LM; Yock, PG; Stertzer, SH; Fitzgerald, PJ;
Indirizzi:
Stanford Univ, Ctr Res Cardiovasc Intervent, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 asc Intervent, Stanford, CA 94305 USA Heart Ctr Siegburg, Siegburg, Germany Heart Ctr Siegburg Siegburg Germany art Ctr Siegburg, Siegburg, Germany Diagnost Inst, Buenos Aires, DF, Argentina Diagnost Inst Buenos Aires DF Argentina nst, Buenos Aires, DF, Argentina Swiss Med Clin, Buenos Aires, DF, Argentina Swiss Med Clin Buenos Aires DF Argentina in, Buenos Aires, DF, Argentina
Titolo Testata:
CIRCULATION
fascicolo: 4, volume: 104, anno: 2001,
pagine: 380 - 383
SICI:
0009-7322(20010724)104:4<380:NDS-IU>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PORCINE CORONARY-ARTERIES; CELL-PROLIFERATION; IMPLANTATION; PACLITAXEL; RESTENOSIS;
Keywords:
coronary disease; drugs; stents; restenosis; ultrasonics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Fitzgerald, PJ Stanford Univ, Ctr Res Cardiovasc Intervent, 300 Pasteur Dr,Room H3554, Stanford, CA 94305 USA Stanford Univ 300 Pasteur Dr,Room H3554Stanford CA USA 94305
Citazione:
Y. Honda et al., "Novel drug-delivery stent - Intravascular ultrasound observations from thefirst human experience with the QP2-eluting polymer stent system", CIRCULATION, 104(4), 2001, pp. 380-383

Abstract

Background-The aim of this study was to use serial intravascular ultrasound (IVUS) to evaluate the long-term effect of stent-based 7-hexanoyltaxol (QP2, a taxane analogue) delivery on neointimal tissue growth within the stent and on vessel dimensions at the adjacent reference segments. Methods and Results-Serial IVUS analyses (immediately after intervention and at follow-up at 8.3 months) were performed in 15 native coronary lesionstreated with the QuaDS-QP2 stent. IVUS measurements were performed at 8 cross-sections in each target segment (4 cross-sections within the stent and 2 cross-sections in each reference segment). At baseline, no significant plaque protrusion or thrombus was detected in the target segment. Mild incomplete stent apposition and edge dissection were observed in one and two cases, respectively. Percent expansion of the stent (minimum stent area/averagereference lumen area) was 96.0 +/- 21.7%. At follow-up, mean neointimal area within the stent was 1.2 +/-1.3 mm(2), and mean cross-sectional narrowing (neointimal area/stent area) was 13.6 +/- 14.9%. At the vessel segments immediately adjacent to the stent, a significant increase in plaque area (1.9 +/-2.6 mm(2), P=0.001) was observed, but vessel area remained unchanged. However, no patients showed clinically significant in-stent or edge restenosis (diameter stenosis greater than or equal to 50%) during the follow-up period. Conclusions-The first human experience with the new drug-delivery stent showed a minimal amount of neointimal proliferation in the stented segment. Late lumen loss at the reference sites adjacent to the stent was acceptable and predominantly due to plaque proliferation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:45:32