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Titolo:
HPLC behavior and hydrophobic parameters of some anilides
Autore:
Djakovic-Sekulic, TL; Petrovic, SM; Perisic-Janjic, NU; Petrovic, SD;
Indirizzi:
Univ Novi Sad, Fac Sci, Inst Chem, YU-21000 Novi Sad, Yugoslavia Univ NoviSad Novi Sad Yugoslavia YU-21000 YU-21000 Novi Sad, Yugoslavia Univ Novi Sad, Fac Technol, YU-21000 Novi Sad, Yugoslavia Univ Novi Sad Novi Sad Yugoslavia YU-21000 YU-21000 Novi Sad, Yugoslavia Univ Belgrade, Fac Technol & Met, YU-11000 Belgrade, Yugoslavia Univ Belgrade Belgrade Yugoslavia YU-11000 YU-11000 Belgrade, Yugoslavia
Titolo Testata:
CHROMATOGRAPHIA
fascicolo: 1-2, volume: 54, anno: 2001,
pagine: 60 - 64
SICI:
0009-5893(200107)54:1-2<60:HBAHPO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHASE LIQUID-CHROMATOGRAPHY; WATER PARTITION-COEFFICIENTS; THIN-LAYER CHROMATOGRAPHY; CAPACITY FACTOR; LIPOPHILICITY; DERIVATIVES; INTERCEPT; SLOPE; TLC;
Keywords:
column liquid chromatography; hydrophobicity; multiple regression analysis; anilides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Perisic-Janjic, NU Univ Novi Sad, Fac Sci, Inst Chem, Trg D Obradovica 3, YU-21000 Novi Sad, Yugoslavia Univ Novi Sad Trg D Obradovica 3 Novi Sad Yugoslavia YU-21000
Citazione:
T.L. Djakovic-Sekulic et al., "HPLC behavior and hydrophobic parameters of some anilides", CHROMATOGR, 54(1-2), 2001, pp. 60-64

Abstract

The chromatographic behavior of para substituted anilides of 2,2-dimethylpropanoic, benzoic and alpha -phenyl acetic acid has been studied by reversed-phase high performance liquid chromatography HPLC was performed on a C-18column with various aqueous methanol mobile phases. The Influence on the retention of anilide type and additional substituents in the molecule is discussed. Several chromatographic hydrophobicity parameters (CHP) have been calculated by linear correlation between log k of the investigated compounds and the concentration of methanol in the mobile phase. The chromatographic hydrophobicity parameters were compared with the log P values calculated by Rekker's fragmental method. The results show moderate correlations of CHIP with log Mus, multiple linear regressions have been applied. It was found that besides log P even the electronic effects of individual polar groups capableof hydrogen bonding proved to be very important in hydrophobic characterization of the molecule.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:30:12